학술논문
Platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and monocyte-to-HDL cholesterol ratio as helpful biomarkers for patients hospitalized for deep vein thrombosis
Document Type
Academic Journal
Author
Source
International Journal of Molecular Medicine. June 2023, Vol. 51 Issue 6, p1D, 6 p.
Subject
Language
English
ISSN
1107-3756
Abstract
Introduction Deep vein thrombosis (DVT) of the lower limbs is often clinically silent (1), and the lack of specificity and sensitivity of symptoms and signals often lead to an ambiguous [...]
There is an increased interest for novel biomarkers in order to improve the diagnostic accuracy for deep vein thrombosis (DVT). Moreover, the link between inflammation and venous thromboembolism has attracted increasing research interests. The present study aimed to evaluate the role of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) as biomarkers for acute DVT. For this purpose, 300 consecutive patients who were hospitalized were considered; 33 patients out of the 300 were admitted for acute DVT of the lower limbs. The PLR, NLR and MHR, as well as the acute phase inflammation markers (leukocytes, neutrophils, C-reactive protein and fibrinogen) were measured. The patients with DVT exhibited significantly higher levels of PLR, NLR and MHR compared to those without DVT (P Key words: deep vein thrombosis, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, monocyte-to-HDL cholesterol ratio, inflammation, biomarkers
There is an increased interest for novel biomarkers in order to improve the diagnostic accuracy for deep vein thrombosis (DVT). Moreover, the link between inflammation and venous thromboembolism has attracted increasing research interests. The present study aimed to evaluate the role of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) as biomarkers for acute DVT. For this purpose, 300 consecutive patients who were hospitalized were considered; 33 patients out of the 300 were admitted for acute DVT of the lower limbs. The PLR, NLR and MHR, as well as the acute phase inflammation markers (leukocytes, neutrophils, C-reactive protein and fibrinogen) were measured. The patients with DVT exhibited significantly higher levels of PLR, NLR and MHR compared to those without DVT (P Key words: deep vein thrombosis, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, monocyte-to-HDL cholesterol ratio, inflammation, biomarkers