학술논문
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. July 15, 1993, Vol. 90 Issue 14, p6449, 5 p. table
Subject
Language
ISSN
0027-8424
Abstract
Researchers inoculated transgenic mice expressing the Syrian hamster prion protein (PrP) with three separate prion isolates to analyze the molecular reasons for prion diversity. The cell-specific spread of prion isolates may be the cause for the distinct characteristics that each of the isolates posess. The three isolates compared were Sc 237, 139H, and Me7H in Tg(SHaPrP)7 mice with clinical indications of scrapie because the incubation periods for hamsters are significantly longer than those for these mice.