학술논문
Propagation of prions with artificial properties in transgenic mice expressingchimeric PrP genes
Document Type
Academic Journal
Author
Source
Cell. June 4, 1993, Vol. 73 Issue 5, p979, 10 p. table
Subject
Language
ISSN
0092-8674
Abstract
Transgenic mice with chimeric prior protein genes derived from Syrian hamster and mouse genes show, when constructed, that one Syrian hamster gene designated MH2M PrP contains five amino acid substitutions while another construct, designated MHM2 PrP, has possess two substitutions. Transgenic MH2M PrP mice were vulnerable to both Syrian hamster and mouse prions. Findings of the study support genetic evidence for homophilic intercourse between PrPSc in the inoculum and Prpc absorbed by the host.