학술논문
A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
Document Type
Academic Journal
Source
Proceedings of the National Academy of Sciences of the United States. July 3, 1995, Vol. 92 Issue 14, p6522, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
Highly inducible and reversible gene expression in cultured cells and transgenic mice is obtained by tetracycline-regulated system (pTet-tTAK). This shows that mice develop normally in presence of tetracycline and transgene. Induction by removal of tetracycline does not effect the mice in their ability to breed. Autoregulatory system, pTet-tTAK is used in the study of gene function in transfected cells and creation of diseased models for testing of therapeutic agents.