부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1365-2141.2007.06842.x Byline: Youn K. Shim (1), Sharon R. Silver (2), Neil E. Caporaso (3), Gerald E. Marti (4), Dannie C. Middleton (1), Martha S. Linet (3), Robert F. Vogt (5) Keywords: chronic lymphocytic leukaemia; monoclonal B-cell lymphocytosis; aetiology; genetics Abstract: Summary The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled 'Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors'. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan. Author Affiliation: (1)Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA (2)Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH (3)Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (4)Office of Cellular, Tissue and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, MD, (5)Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA Article note: Dr Y. K. Shim, Division of Health Studies, Agency for Toxic Substances and Disease Registry (MS: E-31), 1600 Clifton Road, NE, Atlanta, GA 30333, USA. E-mail: YShim@cdc.gov