학술논문
Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
Document Type
Report
Author
Lee, Ho; Chubachi, Shotaro; Namkoong, Ho; Asakura, Takanori; Tanaka, Hiromu; Otake, Shiro; Nakagawara, Kensuke; Morita, Atsuho; Fukushima, Takahiro; Watase, Mayuko; Kusumoto, Tatsuya; Masaki, Katsunori; Kamata, Hirofumi; Ishii, Makoto; Hasegawa, Naoki; Harada, Norihiro; Ueda, Tetsuya; Ueda, Soichiro; Ishiguro, Takashi; Arimura, Ken; Saito, Fukuki; Yoshiyama, Takashi; Nakano, Yasushi; Mutoh, Yoshikazu; Suzuki, Yusuke; Murakami, Koji; Okada, Yukinori; Koike, Ryuji; Kitagawa, Yuko; Kimura, Akinori; Imoto, Seiya; Miyano, Satoru; Ogawa, Seishi; Kanai, Takanori; Fukunaga, Koichi; Takahashi, Kazuhisa; Naito, Toshio; Hiki, Makoto; Matsushita, Yasushi; Takagi, Haruhi; Aoki, Ryousuke; Nakamura, Ai; Harada, Sonoko; Sasano, Hitoshi; Ikemura, Shinnosuke; Okamori, Satoshi; Terai, Hideki; Sasaki, Junichi; Morisaki, Hiroshi; Uwamino, Yoshifumi; Nanki, Kosaku; Mikami, Yohei; Uchida, Sho; Uno, Shunsuke; Ishihara, Rino; Matsubara, Yuta; Nishimura, Tomoyasu; Ogawa, Takunori; Sato, Toshiro; Azuma, Masanori; Saito, Ryuichi; Sado, Toshikatsu; Miyazaki, Yoshimune; Sato, Ryuichi; Haruta, Yuki; Nagasaki, Tadao; Yasui, Yoshinori; Hasegawa, Yoshinori; Tada, Ai; Miyawaki, Masayoshi; Yamamoto, Masaomi; Yoshida, Eriko; Hayashi, Reina; Nagasaka, Tomoki; Arai, Sawako; Kaneko, Yutaro; Sasaki, Kana; Isono, Taisuke; Shibata, Shun; Matsui, Yuma; Hosoda, Chiaki; Takano, Kenji; Nishida, Takashi; Kobayashi, Yoichi; Takaku, Yotaro; Takayanagi, Noboru; Tagaya, Etsuko; Kawana, Masatoshi; Nakamori, Yasushi; Yoshiya, Kazuhisa; Yoshihara, Tomoyuki; Wada, Daiki; Iwamura, Hiromu; Kanayama, Syuji; Maruyama, Shuhei; Hasegawa, Takanori; Takahashi, Kunihiko; Anzai, Tatsuhiko; Ito, Satoshi; Endo, Akifumi; Uchimura, Yuji; Miyazaki, Yasunari; Honda, Takayuki; Tateishi, Tomoya; Tohda, Shuji; Ichimura, Naoya; Sonobe, Kazunari; Sassa, Chihiro Tani; Nakajima, Jun; Ai, Masumi; OhtaKokuto, Ken Hiroyuki; Ogata, Hideo; Tanaka, Yoshiaki; Arakawa, Kenichi; Shimoda, Masafumi; Osawa, Takeshi; Nakajima, Yukiko; Anan, Ryusuke; Arai, Ryosuke; Kurihara, Yuko; Harada, Yuko; Nishio, Kazumi; Sato, Tomonori; Takei, Reoto; Hagimoto, Satoshi; Noguchi, Yoichiro; Yamano, Yasuhiko; Sasano, Hajime; Ota, Sho; Nakayama, Sohei; Masuzawa, Keita; Takano, Tomomi; Katayama, Kazuhiko; Yamada, Mitsuhiro; Sugiura, Hisatoshi; Sano, Hirohito; Matsumoto, Shuichiro; Kimura, Nozomu; Ono, Yoshinao; Baba, Hiroaki; Baba, Rie; Arai, Daisuke; Ogura, Takayuki; Takahashi, Hidenori; Hagiwara, Shigehiro; Nagao, Genta; Konishi, Shunichiro; Nakachi, Ichiro; Tateno, Hiroki; Hase, Isano; Yoshida, Shuichi; Suzuki, Shoji; Kawada, Miki; Horinouchi, Hirohisa; Saito, Fumitake; Mitamura, Keiko; Hagihara, Masao; Ochi, Junichi; Uchida, Tomoyuki; Edahiro, Ryuya; Shirai, Yuya; Sonehara, Kyuto; Naito, Tatsuhiko; Yamamoto, Kenichi; Namba, Shinichi; Suzuki, Ken; Shiroyama, Takayuki; Maeda, Yuichi; Nii, Takuro; Noda, Yoshimi; Niitsu, Takayuki; Adachi, Yuichi; Enomoto, Takatoshi; Amiya, Saori; Hara, Reina; Sasa, Noa; Yamada, Shuhei; Kishikawa, Toshihiro; Tomono, Kazunori; Yamada, Kazuto Kato Shuhei; Ueno, Yuya; Suzuki, Motoyuki; Takemoto, Norihiko; Eguchi, Hirotaka; Fukusumi, Takahito; Imai, Takao; Fukushima, Munehisa; Takagaki, Masatoshi; Kishima, Haruhiko; Inohara, Hidenori; Hirata, Haruhiko; Takeda, Yoshito; Kumanogoh, Atsushi; Miyazawa, Naoki; Kimura, Yasuhiro; Sado, Reiko; Sugimoto, Hideyasu; Kamiya, Akane; Kuwahara, Naota; Fujiwara, Akiko; Matsunaga, Tomohiro; Sato, Yoko; Okada, Takenori; Inoue, Takashi; Hirano, Toshiyuki; Kobayashi, Keigo; Takaoka, Hatsuyo; Nishi, Koichi; Nishitsuji, Masaru; Tani, Mayuko; Suzuki, Junya; Nakatsumi, Hiroki; Koh, Hidefumi; Manabe, Tadashi; Funatsu, Yohei; Ito, Fumimaro; Fukui, Takahiro; Shinozuka, Keisuke; Kohashi, Sumiko; Miyazaki, Masatoshi; Shoko, Tomohisa; Kojima, Mitsuaki; Adachi, Tomohiro; Ishikawa, Motonao; Takahashi, Kenichiro; Watanabe, Kazuyoshi; Hirai, Yoshihiro; Kawashima, Hidetoshi; Narita, Atsuya; Niwa, Kazuki; Sekikawa, Yoshiyuki; Sageshima, Hisako; Nakamura, Yoshihiko; Hoshino, Kota; Maruyama, Junichi; Ishikura, Hiroyasu; Takata, Tohru; Ogura, Takashi; Kitamura, Hideya; Hagiwara, Eri; Murohashi, Kota; Okabayashi, Hiroko; Mochimaru, Takao; Nukaga, Shigenari; Satomi, Ryosuke; Oyamada, Yoshitaka; Mori, Nobuaki; Baba, Tomoya; Fukui, Yasutaka; Odate, Mitsuru; Mashimo, Shuko; Makino, Yasushi; Yagi, Kazuma; Hashiguchi, Mizuha; Kagyo, Junko; Shiomi, Tetsuya; Kawamura, Kodai; Ichikado, Kazuya; Nishiyama, Kenta; Muranaka, Hiroyuki; Nakamura, Kazunori; Fuke, Satoshi; Saito, Hiroshi; Tsuchida, Tomoya; Fujitani, Shigeki; Takita, Mumon; Morikawa, Daiki; Yoshida, Toru; Izumo, Takehiro; Inomata, Minoru; Kuse, Naoyuki; Awano, Nobuyasu; Tone, Mari; Ito, Akihiro; Odani, Toshio; Amishima, Masaru; Hattori, Takeshi; Shichinohe, Yasuo; Kagaya, Takashi; Kita, Toshiyuki; Ohta, Kazuhide; Sakagami, Satoru; Koshida, Kiyoshi; Nakamura, Morio; Yokote, Koutaro; Nakada, Taka-Aki; Abe, Ryuzo; Oshima, Taku; Shimada, Tadanaga; Hayashi, Kentaro; Shimizu, Tetsuo; Kozu, Yutaka; Hiranuma, Hisato; Gon, Yasuhiro; Izumi, Namiki; Nagata, Kaoru; Ueda, Ken; Taki, Reiko; Hanada, Satoko; Hashimoto, Naozumi; Wakahara, Keiko; Sakamoto, Koji; Omote, Norihito; Ando, Akira; Kusaka, Yu; Ohba, Takehiko; Isogai, Susumu; Ogawa, Aki; Inoue, Takuya; Kodama, Nobuhiro; Kaneyama, Yasunari; Maeda, Shunsuke; Kuraki, Takashige; Matsumoto, Takemasa; Harada, Masahiro; Takahashi, Takeshi; Ono, Hiroshi; Sakurai, Toshihiro; Shibusawa, Takayuki; Kawamura, Yusuke; Nakayama, Akiyoshi; Matsuo, Hirotaka; Kimizuka, Yoshifumi; Kawana, Akihiko; Sano, Tomoya; Watanabe, Chie; Suematsu, Ryohei; Masuda, Makoto; Wakabayashi, Aya; Watanabe, Hiroki; Ueda, Suguru; Nishikawa, Masanori; YoshifujiIto, Ayumi Kazuto; Takahashi, Saeko; Ishioka, Kota; Chihara, Yusuke; Takeuchi, Mayumi; Onoi, Keisuke; Shinozuka, Jun; Sueyoshi, Atsushi; Nagasaki, Yoji; Okamoto, Masaki; Tokunaga, Yoshihisa; Ishihara, Sayoko; Shimo, Masatoshi; Watanabe, Masafumi; Inoue, Sumito; Igarashi, Akira; Sato, Masamichi; Hizawa, Nobuyuki; Inoue, Yoshiaki; Chiba, Shigeru; Yamagata, Kunihiro; Kai, Hirayasu; Hiramatsu, Yuji; Fukuyama, Satoru; Kan-o, Keiko; Matsumoto, Koichiro; Eriguchi, Yoshihiro; Yonekawa, Akiko; Kanaoka, Kensuke; Ihara, Shoichi; Komuta, Kiyoshi; Asano, Koichiro; Oguma, Tsuyoshi; Ito, Yoko; Hashimoto, Satoru; Yamasaki, Masaki; Kasamatsu, Yu; Komase, Yuko; Hida, Naoya; Tsuburai, Takahiro; Oyama, Baku; Kitagawa, Yuichiro; Fukuta, Tetsuya; Miyake, Takahito; Yoshida, Shozo; Ogura, Shinji; Takada, Minoru; Kanda, Hidenori; Abe, Shinji; Kono, Yuta; Togashi, Yuki; Takoi, Hiroyuki; Kikuchi, Ryota; Ogawa, Shinichi; Ogata, Tomouki; Ishihara, Shoichiro; Kanehiro, Arihiko; Ozaki, Shinji; Fuchimoto, Yasuko; Wada, Sae; Fujimoto, Nobukazu; Nishiyama, Kei; Terashima, Mariko; Beppu, Satoru; Yoshida, Kosuke; Narumoto, Osamu; Nagai, Hideaki; Ooshima, Nobuharu; Motegi, Mitsuru; Umeda, Akira; Miyagawa, Kazuya; Shimada, Hisato; Endo, Mayu; Ohira, Yoshiyuki; Sagara, Hironori; Tanaka, Akihiko; Ohta, Shin; Kimura, Tomoyuki; Shibata, Yoko; Tanino, Yoshinori; Nikaido, Takefumi; Minemura, Hiroyuki; Sato, Yuki; Yamada, Yuichiro; Hashino, Takuya; Shinoki, Masato; Iwagoe, Hajime; Takahashi, Hiroshi; Fujii, Kazuhiko; Kishi, Hiroto; Ishii, Tomoo; Kanai, Masayuki; Imamura, Tomonori; Yamashita, Tatsuya; Yatomi, Masakiyo; Maeno, Toshitaka; Hayashi, Shinichi; Takahashi, Mai; Kuramochi, Mizuki; Kamimaki, Isamu; Tominaga, Yoshiteru; Utsugi, Mitsuyoshi; Ono, Akihiro; Tanaka, Toru; Kashiwada, Takeru; Fujita, Kazue; Saito, Yoshinobu; Seike, Masahiro; Kanai, Masahiro; Saiki, Ryunosuke; Nannya, Yasuhito; Hyugaji, Takayoshi; Shimizu, Eigo; Katayama, Kotoe; Miyawaki, Satoru; Takahashi, Meiko; Matsuda, Fumihiko; Omae, Yosuke; Tokunaga, Katsushi; Ueno, Takafumi
Source
BMC Infectious Diseases. December 12, 2022, Vol. 22 Issue 1
Subject
Language
English
ISSN
1471-2334
Abstract
Author(s): Ho Lee[sup.1] , Shotaro Chubachi[sup.1] , Ho Namkoong[sup.2] , Takanori Asakura[sup.1] , Hiromu Tanaka[sup.1] , Shiro Otake[sup.1] , Kensuke Nakagawara[sup.1] , Atsuho Morita[sup.1] , Takahiro Fukushima[sup.1] , Mayuko Watase[sup.1] [...]
Background We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. Methods We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged [greater than or equal to] 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021. Results Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, [+ or -] 18.9]) and fifth (mean age, 50.7 years [SD [+ or -] 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD [+ or -] 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave. Conclusions We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation. Keywords: COVID-19, Wave of infection, Respiratory infection, Hospitalization
Background We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. Methods We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged [greater than or equal to] 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021. Results Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, [+ or -] 18.9]) and fifth (mean age, 50.7 years [SD [+ or -] 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD [+ or -] 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave. Conclusions We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation. Keywords: COVID-19, Wave of infection, Respiratory infection, Hospitalization