학술논문
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
Document Type
Author abstract
Report
Report
Author
Source
Proceedings of the National Academy of Sciences of the United States. April 28, 2009, Vol. 106 Issue 17, p7119, 6 p.
Subject
Language
English
ISSN
0027-8424
Abstract
IL-1 causes a marked increase in the degree of expansion of naive and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1[beta], is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in [IL-1R1.sup.-/-] recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1[beta] enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to [IL-1R1.sup.-/-] recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by [approximately equal to] 55%. These results indicate that IL-[beta] signaling in T cells markedly induces robust and durable primary and secondary CD4 responses. cytokines | inflammasome | Th1 | Th17 | Th2