부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mvr.2008.05.001 Byline: Dirk Uhlmann (a), Heike Lauer (b), Frederik Serr (a), Helmut Witzigmann (b) Keywords: Pancreatitis; Platelets; Ischemia; Reperfusion Abstract: The most successful approach for restoring normal long-term glucose homeostasis in type I diabetes mellitus is whole-organ pancreas transplantation. Graft pancreatitis is observed in up to 20% of patients and may lead to loss of the transplanted organ. Several pathophysiological events have been implicated in this form of pancreatitis. The most important cause of early graft pancreatitis is ischemia/reperfusion (I/R)-related disturbance of microvascular perfusion with subsequent hypoxic tissue damage. Recently, considerable evidence accumulated that, among a variety of other pathophysiological events, the activation of platelets can contribute to I/R injury in the course of acute pancreatitis experimentally and clinically. This review summarizes the events affecting platelet function and, therefore, pancreatic microcirculation leading to acute pancreatitis. Therapeutic approaches and own results are presented. Author Affiliation: (a) 2nd Department of Surgery, University of Leipzig, Germany (b) Department of Surgery, Hospital Dresden-Friedrichstadt, Germany Article History: Received 14 February 2008; Revised 23 April 2008; Accepted 29 May 2008