학술논문
Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle
Document Type
Report
Author
Source
Journal of the American Chemical Society. Oct 28, 2009, Vol. 131 Issue 42, 15522-15527
Subject
Language
English
ISSN
0002-7863
Abstract
A new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle is described by using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. The agent has offered several-fold computed tomographic (CT) signal enhancement in vitro and in vivo showing detection sensitivity reaching to the low nanomolar particulate concentration range.