학술논문
Fibrinogen blocks the autoactivation and thrombin-mediated activation of factor XI on dextran sulfate
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. Dec 1, 1992, Vol. 89 Issue 23, p11189, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
The effect of fibrinogen and high molecular weight kininogen (HK) on the autoactivation rate of factor XI on dextran sulfate (DS) as well ason the thrombin and activated-factor XII-mediated activation rate of factor XI on DS was investigated. Thrombin has been implicated to have a role in an alternate pathway for factor XI activation during blood coagulation, since normal or near-normal hemostasis has been observed in subjects that lack one ofthe three contact-system enzymes. It was shown that fibrinogen virtually abolished the autoactivation and the thrombin-mediated activation of factor XI,indicating that thrombin is not part of the alternate pathway.