부산대학교 도서관

Background Torsion shear angle [phi] is an important measure of left ventricular (LV) systolic and diastolic functions. Here we provide a novel index utilizing LV normalized torsion shear angle [phi]^ volume V^ loop to assess LV diastolic functional properties. We defined the area within [phi]^V^ loop as torsion hysteresis area, and hypothesized that it may be an important global parameter of diastolic function. We evaluated the [phi]^ changes to increased V^ during early diastole -d[phi]^/dV^ as a potential measure of LV suction. Methods Sixty resistant hypertension patients (HTN), forty control volunteers were studied using cardiovascular magnetic resonance with tissue tagging. Volumetric and torsional parameters were evaluated. Results HTN demonstrated concentric remodeling with preserved ejection fraction. HTN had significantly decreased normalized early filling rate, early diastolic mitral annulus velocity and E/A (1.33 [+ or -] 1.13 vs. 2.19 [+ or -] 1.07, P < 0.0001) vs. control. Torsion hysteresis area was greater (0.11 [+ or -] 0.07 vs. 0.079 [+ or -] 0.045, P < 0.001) and peak -d[phi]^/dV^ at early diastole was higher (10.46 [+ or -] 8.51 vs. 6.29 [+ or -] 3.85, P = 0.002) than control. Torsion hysteresis area was significantly correlated with E/A (r = -0.23, P = 0.025). Thirteen HTN patients had both E/A ratio < 1.12 (Control mean E/A-1SD) and torsion hysteresis area > 0.12 (Control mean torsion hysteresis area + 1SD). Conclusions Torsion hysteresis area and peak early diastolic -d[phi]^/dV^ were significantly increased in hypertensive concentric remodeling. The [phi]^V^ loop takes into account the active and passive recoil processes of LV diastolic and systolic phases, therefore provides a new global description of LV diastolic function. Keywords: Torsion hysteresis area, [phi]^V^loop, Diastolic function, Cardiovascular magnetic resonance
Author(s): Chun G Schiros[sup.1] , Ravi V Desai[sup.1] , Bharath Ambale Venkatesh[sup.2] , Krishna K Gaddam[sup.1] , Shilpi Agarwal[sup.1] , Steven G Lloyd[sup.1,3] , David A Calhoun[sup.1] , Thomas S [...]