학술논문
Residual respiratory impairment after COVID-19 pneumonia
Document Type
Report
Author
Lombardi, Francesco; Calabrese, Angelo; Iovene, Bruno; Pierandrei, Chiara; Lerede, Marialessia; Varone, Francesco; Richeldi, Luca; Sgalla, Giacomo; Landi, Francesco; Gremese, Elisa; Bernabei, Roberto; Fantoni, Massimo; Gasbarrini, Antonio; Romano Settanni, Carlo; Benvenuto, Francesca; Bramato, Giulia; Carf??, Angelo; Ciciarello, Francesca; Rita Lo Monaco, Maria; Maria Martone, Anna; Marzetti, Emanuele; Napolitano, Carmen; Pagano, Francesco; Rocchi, Sara; Rota, Elisabetta; Salerno, Andrea; Tosato, Matteo; Tritto, Marcello; Calvani, Riccardo; Catalano, Lucio; Picca, Anna; Savera, Giulia; Tamburrini, Enrica; Borghetti, Alberto; Di Gianbenedetto, Simona; Murri, Rita; Cingolani, Antonella; Ventura, Giulio; Taddei, Eleonora; Moschese, Davide; Ciccullo, Arturo; Stella, Leonardo; Addolorato, Giovanni; Franceschi, Francesco; Mingrone, Gertrude; Assunta Zocco, Maria; Sanguinetti, Mauirizio; Cattani, Paola; Marchetti, Simona; Bizzarro, Alessandro; Lauria, Alessandra; Rizzo, Stanislao; Cristina Savastano, Maria; Gambini, Gloria; Grazia Cozzupoli, Maria; Culiersi, Carola; Cesare Passali, Giulio; Paludetti, Gaetano; Galli, Jacopo; Crudo, Fabrizio; Di Cintio, Giovanni; Longobardi, Ylenia; Tricarico, Laura; Santantonio, Mariaconsiglia; Buonsenso, Danilo; Valentini, Piero; Pata, Davide; Sinatti, Davide; De Rose, Cristina.; Calabrese, Aangelo; Sani, Gabriele; Janiri, Delfina; Giuseppin, Giulia; Molinaro, Marzia; Modica, Marco; Natale, Luigi; Rita Larici, Anna; Marano, Riccardo; Paglionico, Annamaria; Petricca, Luca; Gigante, Laura; Natalello, Gerlando; Laura. Fedele, Anna; Maria Lizzio, Marco; Santoliquido, Angelo; Santoro, Luca; Nesci, Antonio; Popolla, Valentina
Source
BMC Pulmonary Medicine. July 17, 2021, Vol. 21 Issue 1
Subject
Language
English
ISSN
1471-2466
Abstract
Author(s): Francesco Lombardi[sup.1,2] , Angelo Calabrese[sup.1,2] , Bruno Iovene[sup.1] , Chiara Pierandrei[sup.2] , Marialessia Lerede[sup.2] , Francesco Varone[sup.1] , Luca Richeldi[sup.1,2] , Giacomo Sgalla[sup.1] , Francesco Landi[sup.] , Elisa Gremese[sup.] [...]
Introduction The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO.sub.2/FiO.sub.2 (p/F) values. Method Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 [+ or -] 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 [+ or -] 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p < 0.001). Patients with p/F below 200 during hospitalization had lower percent predicted forced vital capacity (p = 0.005), lower percent predicted total lung capacity (p = 0.012), lower DLCO (p < 0.001) and shorter 6MWT distance (p = 0.004) than patients with higher p/F. Conclusion Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization. Keywords: COVID, dyspnoea, cough, ABG, PFT, 6MWT
Introduction The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO.sub.2/FiO.sub.2 (p/F) values. Method Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 [+ or -] 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 [+ or -] 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p < 0.001). Patients with p/F below 200 during hospitalization had lower percent predicted forced vital capacity (p = 0.005), lower percent predicted total lung capacity (p = 0.012), lower DLCO (p < 0.001) and shorter 6MWT distance (p = 0.004) than patients with higher p/F. Conclusion Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization. Keywords: COVID, dyspnoea, cough, ABG, PFT, 6MWT