학술논문
Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy
SHORT COMMUNICATION
SHORT COMMUNICATION
Document Type
Academic Journal
Source
Supportive Care in Cancer. December 2012, Vol. 20 Issue 12, p3373, 5 p.
Subject
Language
English
ISSN
0941-4355
Abstract
Introduction Oral mucositis is one of the most serious problems associated with oral cancer radiotherapy [1-3]. Oral mucositis causes substantial pain, bleeding, interferes with the patient's ability to eat, and [...]
Purpose The association between body mass index (BMI) and oral mucositis in oral cancer patients receiving radiotherapy is unclear. This study examined whether low BMI could be a risk factor for oral mucositis in oral cancer patients receiving radiotherapy. Methods Between April 2007 and March 2011, a total of 33 inpatients with oral cancer receiving radiotherapy were recruited. They were followed from the beginning of radiotherapy to discharge from hospital. All patients had no mucositis when radiotherapy started. The odds ratio (OR) and 95% confidence interval (CI) of BMI for incident grade 2 and grade 3 mucositis were calculated by use of univariable logistic regression models. Results All patients developed oral mucositis (grade 1 in 39.4%, grade 2 in 30.3%, grade 3 in 30.3%), with the maximum grade occurring at an average of 32.4 days. Compared with normal BMI ([greater than or equal to] 22.0), the OR of low BMI (< 22.0) for moderate to severe mucositis was 9.07 (95% CI, 1.72-47.68). Conclusions Low BMI may be a risk factor of moderate to severe oral mucositis. Keywords Oral cancer * Oral mucositis * Radiotherapy * Risk factors
Purpose The association between body mass index (BMI) and oral mucositis in oral cancer patients receiving radiotherapy is unclear. This study examined whether low BMI could be a risk factor for oral mucositis in oral cancer patients receiving radiotherapy. Methods Between April 2007 and March 2011, a total of 33 inpatients with oral cancer receiving radiotherapy were recruited. They were followed from the beginning of radiotherapy to discharge from hospital. All patients had no mucositis when radiotherapy started. The odds ratio (OR) and 95% confidence interval (CI) of BMI for incident grade 2 and grade 3 mucositis were calculated by use of univariable logistic regression models. Results All patients developed oral mucositis (grade 1 in 39.4%, grade 2 in 30.3%, grade 3 in 30.3%), with the maximum grade occurring at an average of 32.4 days. Compared with normal BMI ([greater than or equal to] 22.0), the OR of low BMI (< 22.0) for moderate to severe mucositis was 9.07 (95% CI, 1.72-47.68). Conclusions Low BMI may be a risk factor of moderate to severe oral mucositis. Keywords Oral cancer * Oral mucositis * Radiotherapy * Risk factors