학술논문
Elevated Serum Vinculin in Patients with HBV/ HCV-Associated Liver Cirrhosis and Hepatocellular Carcinoma: A Pilot Study
ORIGINAL RESEARCH
ORIGINAL RESEARCH
Document Type
Report
Author
Source
Biologics: Targets and Therapy. March 31, 2023, Vol. 17, p23, 9 p.
Subject
Language
English
ISSN
1177-5475
Abstract
Introduction Hepatocellular carcinoma (HCC) is a kind of liver cancer that mostly affects people with chronic liver disease and cirrhosis. HCC morbidity has increased in recent decades, and it now [...]
Background: The stiffness of the extracellular matrix (ECM) controls many cellular processes, such as migration and differentiation. Cells detect stiffness through adhesion structures termed focal adhesions (FAs). Vinculin, an actin-binding FA protein, plays a pivotal role in FA-mediated mechanotransduction. Aim: This study aimed to explore the role of vinculin in the development of HBV/HCV-induced hepatocellular carcinoma (HCC). Methods: Vinculin levels in a total number of 100 serum samples from patients with HBV/HCV-induced liver cirrhosis and HCC, as well as healthy controls, were analyzed using an enzyme-linked immunosorbent assay (ELISA). Results: In patients with HCC and liver cirrhosis, the serum vinculin levels were significantly greater than in controls (503.8 [+ or -] 242.2 and 728.4 [+ or -] 1044.8 vs 77.7 [+ or -] 36.1 respectively, p Conclusion: Patients with HBVor HCV-induced liver cirrhosis and HCC have significantly higher serum levels of vinculin than do controls. This might point to a potential role for vinculin in the development of HCC. More research into how this protein affects the development of HCC at the molecular level could lead to better clinical treatments and the development of new molecular therapies. Keywords: vinculin, HCC, extracellular matrix, liver cirrhosis, focal adhesion proteins
Background: The stiffness of the extracellular matrix (ECM) controls many cellular processes, such as migration and differentiation. Cells detect stiffness through adhesion structures termed focal adhesions (FAs). Vinculin, an actin-binding FA protein, plays a pivotal role in FA-mediated mechanotransduction. Aim: This study aimed to explore the role of vinculin in the development of HBV/HCV-induced hepatocellular carcinoma (HCC). Methods: Vinculin levels in a total number of 100 serum samples from patients with HBV/HCV-induced liver cirrhosis and HCC, as well as healthy controls, were analyzed using an enzyme-linked immunosorbent assay (ELISA). Results: In patients with HCC and liver cirrhosis, the serum vinculin levels were significantly greater than in controls (503.8 [+ or -] 242.2 and 728.4 [+ or -] 1044.8 vs 77.7 [+ or -] 36.1 respectively, p Conclusion: Patients with HBVor HCV-induced liver cirrhosis and HCC have significantly higher serum levels of vinculin than do controls. This might point to a potential role for vinculin in the development of HCC. More research into how this protein affects the development of HCC at the molecular level could lead to better clinical treatments and the development of new molecular therapies. Keywords: vinculin, HCC, extracellular matrix, liver cirrhosis, focal adhesion proteins