부산대학교 도서관

Introduction We sought to evaluate the effect of age on postoperative outcomes among patients undergoing major liver surgery for perihilar cholangiocarcinoma (PHCC). Methods 77 patients were included. Patients were categorized into two groups: the '< 70-year-olds' group (n = 54) and the '[greater than or equal to] 70-year-olds' group (n = 23). Results Median LOS was 19 both for < 70-year-old group and [greater than or equal to] 70-year-old group (P = 0.72). No differences in terms of severe complication were detected (44.4% Clavien-Dindo 3-4-5 in < 70-year-old group vs 47.8% in [greater than or equal to] 70-year-old group, P = 0.60). Within 90 postoperative days, 11 patients died, 6 in < 70-year-old group (11.3%) and 5 in [greater than or equal to] 70-year-old group (21.7%), P = 0.29. The median follow-up was 20 months. The death rate was 72.2% and 78.3% among patients < 70 years old and [greater than or equal to] 70 years old. The OS at 2 and 5 years was significantly higher among the < 70 years old (57.0% and 27.7%) compared to the [greater than or equal to] 70 years old (27.1% and 13.6%), P = 0.043. Adjusting for hypertension and Charlson comorbidity index in a multivariate analysis, the HR for age was 1.93 (95% CI 0.84-4.44), P = 0.12. Relapse occurred in 43 (81.1%) patients in the < 70-year-old group and in 19 (82.6%) patients in the [greater than or equal to] 70-year-old group. DFS at 12, 24, and 36 months was, respectively, 59.6, 34.2, and 23.2 for the < 70 -year-old group and 32.5, 20.3, and 13.5 for the [greater than or equal to] 70-year-old group (P = 0.26). Adjusting for hypertension and Charlson comorbidity index in a Cox model, the HR for age was 1.52 (95% CI 0.67-3.46), with P = 0.32. Conclusions [greater than or equal to] 70-year-old patients with PHCC can still be eligible for major liver resection with acceptable complication rates and should not be precluded a priori from a radical treatment.
Author(s): L. Ripamonti [sup.1] [sup.2], R. De Carlis [sup.1], A. Lauterio [sup.1], I. Mangoni [sup.1], S. Frassoni [sup.3], V. Bagnardi [sup.3], L. Centonze [sup.1], C. Poli [sup.1], V. Buscemi [sup.1], [...]