학술논문
The number of tumour-infiltrating TIA-1+ cytotoxic T cells but not FOXP3+ regulatory T cells predicts outcome in diffuse large B-cell lymphoma
Document Type
Author abstract
Author
Source
British Journal of Haematology. May, 2007, Vol. 137 Issue 4, p364, 10 p.
Subject
Language
English
ISSN
0007-1048
Abstract
To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1365-2141.2007.06593.x Byline: Sverker Hasselblom (1), Margret Sigurdadottir (2), Ulrika Hansson (2), Herman Nilsson-Ehle (1), Borje Ridell (2), Per-Ola Andersson (1) Keywords: TIA-1; cytotoxic T cells; FOXP3; T; diffuse large B-cell lymphoma Abstract: Summary The prognostic significance of tumour-infiltrating lymphocytes (TILs) in patients with diffuse large B-cell lymphoma (DLBCL) remains controversial. Furthermore, the possible impact of regulatory T cells (T.sub.regs) on survival in DLBCL is still unknown. We performed a retrospective study on the immunohistochemical expression of cytotoxic cells and T.sub.regs, and their correlation with survival in 195 DLBCL patients. Patients with a small number of cytotoxic T-cell intracytoplasmic antigen-1 (TIA-1)+ T cells ([less than or equal to]260 cells/mm.sup.2 tumour area; n = 52) had significantly better outcome than patients with a large number (>260 cells/mm.sup.2; n = 143); progression-free survival (PFS) at 5 years was 67% vs. 50% (P = 0*03) and overall survival (OS) was 73% vs. 57% (P = 0*03). In multivariate analysis, the low TIA-1+ group still had a better PFS (relative risk 0*75, 95% confidence interval 0*31-0*99; P = 0*05). The number of forkhead box protein 3 (FOXP3)+ T.sub.regs had no influence on PFS (P = 0*89) or OS (P = 0*75). These results suggest that immunohistochemical analysis of cytotoxic T cells at time of diagnosis could provide additional prognostic information. The lack of correlation between the number of FOXP3+ cells and survival could possibly indicate that tumour-infiltrating T.sub.regs are of less clinical importance in DLBCL. However, these findings need to be explored in functional studies. Author Affiliation: (1)Section of Haematology and Coagulation, Department of Internal Medicine (2)Department of Pathology and Cytology, Sahlgrenska University Hospital, Goteborg, Sweden Article History: Received 18 December 2006; accepted for publication 5 March 2007 Article note: Sverker Hasselblom, MD, Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, SE-413 45 Goteborg, Sweden. E-mail: sverker.hasselblom@vgregion.se