학술논문
Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study
Document Type
Report
Author
Baldacci, Filippo; Lista, Simone; Manca, Maria Laura; Chiesa, Patrizia A.; Cavedo, Enrica; Lemercier, Pablo; Zetterberg, Henrik; Blennow, Kaj; Habert, Marie-Odile; Potier, Marie Claude; Dubois, Bruno; Vergallo, Andrea; Hampel, Harald; Bakardjian, Hovagim; Benali, Habib; Bertin, Hugo; Bonheur, Joel; Boukadida, Laurie; Boukerrou, Nadia; Cavedo, Enrica; Chiesa, Patrizia; Colliot, Olivier; Dubois, Bruno; Dubois, Marion; Epelbaum, Stéphane; Gagliardi, Geoffroy; Genthon, Remy; Habert, Marie-Odile; Hampel, Harald; Houot, Marion; Kas, Aurélie; Lamari, Foudil; Levy, Marcel; Lista, Simone; Metzinger, Christiane; Mochel, Fanny; Nyasse, Francis; Poisson, Catherine; Potier, Marie-Claude; Revillon, Marie; Santos, Antonio; Andrade, Katia Santos; Sole, Marine; Surtee, Mohmed; de Schotten, Michel Thiebaut; Vergallo, Andrea; Younsi, Nadjia
Source
Alzheimer's Research & Therapy. November 12, 2020, Vol. 12 Issue 1
Subject
Language
English
ISSN
1758-9193
Abstract
Background Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer's disease (AD). The impact of biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect of sex, age, APOE [epsilon]4 allele, comorbidities, brain amyloid-[beta] (A[beta]) burden, and cognitive scores on plasma NFL and t-Tau concentrations in cognitively healthy individuals with SMC, a condition associated with AD development. Methods Three hundred sixteen and 79 individuals, respectively, have baseline and three-time point assessments (at baseline, 1-year, and 3-year follow-up) of the two biomarkers. Plasma biomarkers were measured with an ultrasensitive assay in a mono-center cohort (INSIGHT-preAD study). Results We show an effect of age on plasma NFL, with women having a higher increase of plasma t-Tau concentrations compared to men, over time. The APOE [epsilon]4 allele does not affect the biomarker concentrations while plasma vitamin B12 deficiency is associated with higher plasma t-Tau concentrations. Both biomarkers are correlated and increase over time. Baseline NFL is related to the rate of A[beta] deposition at 2-year follow-up in the left-posterior cingulate and the inferior parietal gyri. Baseline plasma NFL and the rate of change of plasma t-Tau are inversely associated with cognitive score. Conclusion We find that plasma NFL and t-Tau longitudinal trajectories are affected by age and female sex, respectively, in SMC individuals. Exploring the influence of biological variables on AD biomarkers is crucial for their clinical validation in blood. Keywords: Neurofilament light chain, Tau, Alzheimer's disease, Subjective memory complainers, Mild cognitive impairment, Biomarkers
Author(s): Filippo Baldacci[sup.1,2] , Simone Lista[sup.1,3,4] , Maria Laura Manca[sup.2,5] , Patrizia A. Chiesa[sup.1,3,4] , Enrica Cavedo[sup.1,3,4,6] , Pablo Lemercier[sup.1,3,4] , Henrik Zetterberg[sup.7,8,9,10] , Kaj Blennow[sup.7,8] , Marie-Odile Habert[sup.11,12,13] , [...]
Author(s): Filippo Baldacci[sup.1,2] , Simone Lista[sup.1,3,4] , Maria Laura Manca[sup.2,5] , Patrizia A. Chiesa[sup.1,3,4] , Enrica Cavedo[sup.1,3,4,6] , Pablo Lemercier[sup.1,3,4] , Henrik Zetterberg[sup.7,8,9,10] , Kaj Blennow[sup.7,8] , Marie-Odile Habert[sup.11,12,13] , [...]