학술논문
The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study
Document Type
Report
Author
Hamel, Anne-Laure; Delbos, Léo; Natella, Pierre-André; Radulesco, Thomas; Alexandru, Mihaela; Bartaire, Emmanuel; Bartier, Sophie; Benoite, Gonda; Bequignon, Emilie; Castillo, Laurent; Canouï-Poitrine, Florence; Carsuzaa, Florent; Corré, Alain; Coste, André; Couloigner, Vincent; Daveau, Clémentine; De Boissieu, Paul; De Bonnecaze, Guillaume; De Gabory, Ludovic; Debry, Christian; Deraedt, Simon; Dufour, Xavier; El Bakkouri, Wissame; Gilain, Laurent; Hans, Stéphane; Hautefort, Charlotte; Hermann, Ruben; Jankowski, Roger; La Croix, Candice; Lecanu, Jean-Baptiste; Malard, Olivier; Michel, Justin; Nguyen, Yann; Nevoux, Jerome; Papon, Jean-François; Patron, Vincent; Prigent, Marine; Pruliere-Escabasse, Virginie; Renaud, Marion; Rumeau, Cécile; Salmon, Dominique; Saroul, Nicolas; Serrano, Elie; Nhung Tran Khai, Christine; Tringali, Stéphane; Truy, Eric; Vandersteen, Clair; Verillaud, Benjamin; Veil, Raphaël; Fieux, Maxime
Source
Life (Basel). February, 2024, Vol. 14 Issue 3
Subject
Language
English
ISSN
2075-1729
Abstract
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient’s medical management (outpa-tient care, standard hospital admission, and ICU admission). Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease. Results: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic.
Author(s): Anne-Laure Hamel [1]; Léo Delbos [2,3]; Pierre-André Natella [1]; Thomas Radulesco [4,5]; Mihaela Alexandru [3,6,7]; Emmanuel Bartaire [8,9,10]; Sophie Bartier [11,12,13]; Gonda Benoite [14]; Emilie Bequignon [12,13,15]; Laurent Castillo [...]
Author(s): Anne-Laure Hamel [1]; Léo Delbos [2,3]; Pierre-André Natella [1]; Thomas Radulesco [4,5]; Mihaela Alexandru [3,6,7]; Emmanuel Bartaire [8,9,10]; Sophie Bartier [11,12,13]; Gonda Benoite [14]; Emilie Bequignon [12,13,15]; Laurent Castillo [...]