부산대학교 도서관

Background and objective Data regarding the effects of omega-3 polyunsaturated fatty acids (PUFA) supplementation on metabolic status of pregnant women are limited. This systematic review and meta-analysis were done based on randomized controlled trials (RCTs) dealing with the effects of omega-3 PUFA supplementation on glycemic control, lipoproteins, inflammation and oxidative stress in pregnant women. Methods Following databases were searched for eligible studies published from inception to until 2019: MEDLINE, EMBASE, Web of Science, PubMed, Scopus, Cochrane Library, and Google scholar. Studies that evaluated the effect of omega-3 PUFA supplementation on parameters of glycemic control, lipoproteins, inflammation and oxidative stress in pregnant women were found by using the key MeSH. A study quality assessment was performed using the Cochrane Collaboration risk of bias tool and heterogeneity between studies was statistically computed using Cochrane's Q test and I-square (I.sup.2). Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results No significant effects of omega-3 PUFA supplementation on FPG, insulin, insulin resistance, total cholesterol, triglycerides, LDL-cholesterol, total cholesterol/HDL-cholesterol, interleukin 6 (IL-6), IL-8, and malondialdehyde were found. However, omega-3 PUFA significantly increased serum concentrations of HDL-cholesterol (WMD: 3.10; 95% CI: 0.18, 6.03) and reduced C-reactive protein (WMD: -1.85; 95% CI: -2.61, -1.09). Conclusion Based on the results of this meta-analysis omega-3 PUFA supplementation during pregnancy has a significant beneficial effect on HDL-cholesterol, and C-reactive protein. Keywords: Omega 3 fatty acids, Insulin resistance, Lipoproteins, Inflammation, Oxidative stress, Pregnant woman
Author(s): Elaheh Amirani[sup.1], Zatollah Asemi[sup.1], Omid Asbaghi[sup.2], Alireza Milajerdi[sup.3,4], Željko Reiner[sup.5], Mohammad Ali Mansournia[sup.6], Jamal Hallajzadeh[sup.7], Bahram Moazzami[sup.8] and Shahla Chaichian[sup.8] Introduction Pregnancy is associated with a variety of physiological [...]