부산대학교 도서관

Background: The purpose of this study was to compare apolipoprotein E [epsilon]4 (Apo E [epsilon]4) and apolipoprotein E [epsilon]2 (Apo E [epsilon]2) as predictors of cognitive and functional trajectories over 30 months. Methods: This prospective cohort study included 287 community-dwelling memory clinic patients with dementia, mild cognitive impairment, or no cognitive impairment. The Addenbrooke Cognitive Examination, Mini-Mental State Examination, Montreal Cognitive Assessment, Delirium Index, and Nottingham Instrumental Activities of Daily Living tests were administered to each subject. Results: One hundred and nine subjects (40%) carried Apo E [epsilon]4 and 48 (16.7%) carried Apo E [epsilon]2. One hundred and nine [epsilon]4-positive subjects differed significantly from 178 [epsilon]4-negative subjects in 19/52 comparisons (36.5%), whereas 46 Apo E [epsilon]2-positive subjects had 0/52 significant differences from 239 [epsilon]2-negative subjects (P < 0.0001). The variables most affected by [epsilon]4 were the Delirium Index and Mini-Mental State Examination. Instrumental Activities of Daily Living score and residence were unrelated to Apo E [epsilon]4 or [epsilon]2. Conclusion: Apo E [epsilon]4 positivity predicted four cognitive scores measured every 6 months over 30 months. Apo E [epsilon]2 scores predicted none of 52 comparisons. Keywords: apolipoprotein E genotype, dementia, mild cognitive impairment
Introduction The apolipoprotein E (Apo E) genotype has been studied primarily with respect to the initial diagnosis of Alzheimer's disease. We reviewed 15 Apo E [papers.sup.1-15] representing 21,651 subjects. Apo [...]