학술논문
Serrate2 is disrupted in the mouse limb-development mutant syndactylism
Document Type
Academic Journal
Author
Source
Nature. Oct 16, 1997, Vol. 389 Issue 6652, p722, 4 p.
Subject
Language
ISSN
0028-0836
Abstract
A Notch signalling pathway is involved in the earliest stages of limb-bud patterning, according to research undertaken in mice with the syndactylism (sm) mutation. The results of this research support the view that an ancient genetic mechanism forms the basis for both apical ectodermal ridge (AER) formation in vertebrates and wing-margin formation in flies. There is now a range of circumstantial evidence for a conserved interaction between fringe homologues and Notch pathways.