학술논문
Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
Document Type
Clinical report
Author
Sánchez‐Luna, Manuel; Medrano, Constancio; Lirio, Julián; Suazo, José Antonio Hurtado; Peña, Manuela; López, Eduardo Narbona; Fernández, José Uberos; Jover, Enrique Blanca; Perales, Antonio Bonillo; Delgado, Javier Díes; Montes, Mª Ángeles Ortega; Moreno, Jesús Cruz; Tardío, Joaquín Ortiz; Esteban, Mª Victoria; Millán, Leticia; Peracaula, Carlos Salido; Trujillo, Gloria María Quesada; Pajares, José David Martínez; López, Simón Pedro Lubián; Aranda, Salvador Ariza; Faci, Mª Purificación Ventura; Guillén, Sofía Valle; Lozano, Olga Bueno; Gracia, Segundo Rite; Cabezas, Miguel Ángel García; Ramírez, Natalia Bejarano; Machado, Mª Carmen Fresneda; Gutiérrez, Andrés Martínez; Rodríguez, Sara Rellán; Temprano, Marianela Marcos; Vicente, Elena Ortega; Malfaz, Fernando Centeno; Martín, Laura San Feliciano; Escalero, Ana Remesal; Zaballos, Francisca Benito; Closa‐Monasterolo, Ricardo; Salvadó, Silvia Franch; Sanz, Israel Fernando Anquela; Castells, Joaquim Bosch; Fagundo, Alberto Trujillo; Malfaz, Emma Ametller; Fernández, Mario José Sánchez; Mir, Eduard Solé; Lletget, Wilfredo Coroleu; Carrera, Ignacio Arroyo; Perianes, María Taboada; Pico, Mª Luz Couce; Seara, María José Fernández; Prado, Mª Yolanda Ruiz; Olive, Mª Luisa Poch; Maderuelo, Elena; Zeballos, Susana; Orozco, Ana Leal; Serrano, Cristina Ruíz; Omeñaca, Félix; Palomino, Esperanza Escribano; Guereta, Luis García; Jiménez, Vicente Bosch; Sánchez, José Diego Gutiérrez; Pidre, Manuel Cidrás; Sánchez, Natividad Viguria; Orayen, Concepción Goñi; Unceta‐Barrenechea, Ana Aguirre; Legorburu, Alberto Pérez; Ortuño, Mª José Palao; Crespo, Maribel Giner; Muñoz, Ángel González; Macián, Mª Isabel Izquierdo; Zafra, Rafael Gómez; Colunga, Juan Mayordomo; Zapico, Bárbara Montes; Varas, María Rosón; Matilla, María Mora; Herroz, Ignacio Oulego; Pereira, Mª Teresa Prada; Consuegra, Miguel Ángel Arias; Vilella, Laura Castells; Cazcarra, Jesús Antonio Mairal; Ruiz, Silvia Yévenes; Terrassa, Consorci Sanitàri; Díez, Isabel Sáez; Reymundo, Mercedes García; López, Esther Piñán; Sarabia, Javier Fernández; Cáceres, Sofía Hernández; Lois, Mª Gloria López; Olivas, Cristina; Martin, Mª José Rivero; Ibarra, Susana Heras; Cuadrado, Mercedes; Amador, Jose Tomás Ramos; Martin, Sara Guillén; Díaz, Alfonso Cañete; Corvino, Julia Sopeña; –Puelles, Francisco Javier González‐Valcárcel Sánchez; Sirera, Jose Cambra; García, Begoña Pérez; Candel, Maria Isabel Jiménez; Calvo, Elisa Cueto; Guardia, Leonor; Casero, Julián Lirio; Galiana, Gemma Ginovart; Bernal, Esther López; León, Lorenzo Sánchez; Ferrandez, Maria Jesus; Quiles, Jose Luis; De Elche, H.; Rimblas, Maria; Capaces, Susana Larrosa; De Reus, H. San Joan
Source
Influenza and Other Respiratory Viruses. September 9, 2016, Vol. 11 Issue 2, p157, 8 p.
Subject
Language
English
ISSN
1750-2640
Abstract
Introduction Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity, hospitalization rates including neonatal intensive care unit admission, healthcare burden and mortality. Infants [...]
Background: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. Objectives: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. Patients/Methods: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. Results: The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non‐DS cohort (44.1% vs 7.7%, P Conclusions: Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non‐DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.
Background: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. Objectives: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. Patients/Methods: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. Results: The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non‐DS cohort (44.1% vs 7.7%, P Conclusions: Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non‐DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.