학술논문
Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents
Document Type
Academic Journal
Author
Source
European Journal of Microbiology and Immunology. March 2023, Vol. 13 Issue 1, p77, 6 p.
Subject
Language
English
ISSN
2062-509X
Abstract
INTRODUCTION Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan [1]. This successful parasite cycles between definitive felid hosts and a broad range of intermediate hosts including humans [2]. Toxoplasmosis, [...]
We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1.7%) of the 60 controls (found in prefrontal cortex) (OR: 5.16; 95% CI: 0.61-43.10; P 5 0.14). Results suggest that T. gondii infection in brain is not associated with suicide. Further studies to confirm this finding are needed. KEYWORDS Toxoplasma gondii, suicide, case-control study, immunohistochemistry, epidemiology
We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1.7%) of the 60 controls (found in prefrontal cortex) (OR: 5.16; 95% CI: 0.61-43.10; P 5 0.14). Results suggest that T. gondii infection in brain is not associated with suicide. Further studies to confirm this finding are needed. KEYWORDS Toxoplasma gondii, suicide, case-control study, immunohistochemistry, epidemiology