학술논문
Drug repurposing: progress, challenges and recommendations
Document Type
Report
Author
Source
Nature Reviews Drug Discovery. January 2019, Vol. 18 Issue 1, p41, 18 p.
Subject
Language
English
ISSN
1474-1776
Abstract
Author(s): Sudeep Pushpakom [1]; Francesco Iorio [2]; Patrick A. Eyers [3]; K. Jane Escott [4]; Shirley Hopper [5]; Andrew Wells [6]; Andrew Doig [7]; Tim Guilliams [8]; Joanna Latimer [9]; [...]
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing.
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing.