학술논문
Single mutidrug resistant enterobacteriacae donor-derived infection in four solid organ transplant recipients: a case report
Document Type
Clinical report
Source
BMC Surgery. August 14, 2019, Vol. 19 Issue 1
Subject
Language
English
ISSN
1471-2482
Abstract
Author(s): Eva Kieslichova[sup.1] , Marek Protus[sup.1] , Dana Nemcova[sup.2] and Eva Uchytilova[sup.1] Background Solid organ transplantation (SOT) is the only way to treat end-stage organ disease [1]. However, as the [...]
Background Bacteraemia of the donor is not considered to be contraindication of organ procurement. On the other hand, infection of solid organ transplant recipients remains to be a major cause of their morbidity and mortality. When using organs from bacteraemic donors, individual risks need to be assessed and the appropriate antibiotic treatment applied. Case presentation In this case series we report several serious donor-derived infectious complications in four out of five recipients of different organs from one single donor in the early posttransplant period. Donor-transmitted multi-drug resistant strains of Escherichia coli and Klebsiella pneumonia was confirmed by both serologic and molecular testing. Conclusions To prevent donor-derived infections, careful microbiological screening followed by targeted antibiotic treatment is essential. Although such complications can never by completely prevented, a high index for potential bacterial infection in organ donors and transplant recipients should be routinely employed. Keywords: Donor-derived infection, Multi-drug resistant bacteria, Early posttransplant infection
Background Bacteraemia of the donor is not considered to be contraindication of organ procurement. On the other hand, infection of solid organ transplant recipients remains to be a major cause of their morbidity and mortality. When using organs from bacteraemic donors, individual risks need to be assessed and the appropriate antibiotic treatment applied. Case presentation In this case series we report several serious donor-derived infectious complications in four out of five recipients of different organs from one single donor in the early posttransplant period. Donor-transmitted multi-drug resistant strains of Escherichia coli and Klebsiella pneumonia was confirmed by both serologic and molecular testing. Conclusions To prevent donor-derived infections, careful microbiological screening followed by targeted antibiotic treatment is essential. Although such complications can never by completely prevented, a high index for potential bacterial infection in organ donors and transplant recipients should be routinely employed. Keywords: Donor-derived infection, Multi-drug resistant bacteria, Early posttransplant infection