학술논문
Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study
Document Type
Periodical
Author
Pascual, Stéphanie; Noble, Brooklyn; Ahmad-Saeed, Nusreen; Aldridge, Catherine; Ambretti, Simone; Amit, Sharon; Annett, Rachel; O'Shea, Shaan Ashk; Barbui, Anna Maria; Barlow, Gavin; Barrett, Lucinda; Berth, Mario; Bondi, Alessandro; Boran, Nicola; Boyd, Sara E.; Chaves, Catarina; Clauss, Martin; Davies, Peter; Dianzo-Delgado, Ileana T.; Esteban, Jaime; Fuchs, Stefan; Friis-Hansen, Lennart; Goldenberger, Daniel; Golle, Andrej; Groonroos, Juha O.; Hoffmann, Ines; Hoffmann, Tomer; Hughes, Harriet; Ivanova, Marina; Jezek, Peter; Jones, Gwennan; Ceren Karahan, Zeynep; Lass-Flörl, Cornelia; Laurent, Frédéric; Leach, Laura; Horsbøll Pedersen, Matilde Lee; Loiez, Caroline; Lynch, Maureen; Maloney, Robert J.; Marsh, Martin; Milburn, Olivia; Mitchell, Shanine; Moore, Luke S. P.; Moffat, Lynn; Murdjeva, Marianna; Murphy, Michael E.; Nayar, Deepa; Nigrisoli, Giacomo; O'Sullivan, Fionnuala; Öz, BüÅra; Peach, Teresa; Petridou, Christina; Prinz, Mojgan; Rak, Mitja; Reidy, Niamh; Rossolini, Gian Maria; Roux, Anne-Laure; Ruiz-Garbajosa, Patricia; Saeed, Kordo; Salar-Vidal, Llanos; Salas Venero, Carlos; Selvaratnam, Mathyruban; Senneville, Eric; Starzengruber, Peter; Talbot, Ben; Taylor, Vanessa; TrebÅ¡e, Rihard; Wearmouth, Deborah; Willinger, Birgit; Wouthuyzen-Bakker, Marjan; Couturier, Brianne; Allantaz, Florence
Source
Journal of Bone and Joint Infection (JBJI). February 28, 2024, Vol. 9 Issue 1, p87
Subject
Language
English
ISSN
2206-3552
Abstract
Introduction: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods: A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results: A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4 % and 85 % respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on Staphylococcus aureus, Streptococcus species, Enterococcus faecalis, Kingella kingae, Neisseria gonorrhoeae, and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1 h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies. Conclusion: The study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting.
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To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: https://jbji.copernicus.org/articles/9/87/2024/jbji-9-87-2024.html, or to download the full-text, click the download button on this [...]