학술논문
SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients
Document Type
Report
Author
Emprou, Camille; Van Quyen, Pauline Le; Jégu, Jérémie; Prim, Nathalie; Weingertner, Noëlle; Guérin, Eric; Pencreach, Erwan; Legrain, Michèle; Voegeli, Anne‐Claire; Leduc, Charlotte; Mennecier, Bertrand; Falcoz, Pierre‐Emmanuel; Olland, Anne; Santelmo, Nicolas; Quoix, Elisabeth; Massard, Gilbert; Guenot, Dominique; Chenard, Marie‐Pierre; Beau‐Faller, Michèle
Source
Cancer Medicine. May 29, 2018, Vol. 7 Issue 7, p3278, 14 p.
Subject
Language
English
ISSN
2045-7634
Abstract
INTRODUCTION Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death worldwide. Surgical resection is the best treatment for early stage NSCLC patients (I to IIIA UICC stage), [...]
: Lymph node metastasis is an important prognosis factor in non‐small cell lung cancer (NSCLC) patients. The aim of this study was to investigate the role of epithelial to mesenchymal transition (EMT) in lymph node progression in the early stages of NSCLC. We studied a retrospective cohort of 160 consecutive surgically treated NSCLC patients with available frozen tumor samples for expression of EMT markers (CDH1, CTNNB1, CDH2, and VIMENTIN), inducers (TGFB1, c‐MET, and CAIX), and transcription factors (EMT‐TF:SNAI1, SNAI2, ZEB1, TWIST1, and TWIST2). Partial EMT was more frequent in N1‐2 (N+) vs N0 patients (P
: Lymph node metastasis is an important prognosis factor in non‐small cell lung cancer (NSCLC) patients. The aim of this study was to investigate the role of epithelial to mesenchymal transition (EMT) in lymph node progression in the early stages of NSCLC. We studied a retrospective cohort of 160 consecutive surgically treated NSCLC patients with available frozen tumor samples for expression of EMT markers (CDH1, CTNNB1, CDH2, and VIMENTIN), inducers (TGFB1, c‐MET, and CAIX), and transcription factors (EMT‐TF:SNAI1, SNAI2, ZEB1, TWIST1, and TWIST2). Partial EMT was more frequent in N1‐2 (N+) vs N0 patients (P