학술논문
Scatter factor induces blood vessel formation in vivo
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. March 1, 1993, Vol. 90 Issue 5, p1937, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
Scatter factor (SF) is a cytokine derived from fibroblasts and vascular smooth muscle cells that stimulates cell proliferation and motility. An investigation was conducted to determine if SF exhibits angiogenic activity in vivo. The results showed that physiologic concentrations of SF could induce strong in vivo angiogenic response. In addition, SF could stimulate endothelial cells to produce urokinase, and was detected in developing blood vessels of psoriatic skin. These results indicate that SF is involved in angiogenesis associated with human inflammatory diseases.