부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1365-2141.2007.06870.x Byline: Jane M. Rachel (1), Marjorie L. Zucker (1), Christopher M. Fox (1), Fred V. Plapp (1), Jay E. Menitove (2), Fatima Abbasi (3), Gerald E. Marti (3) Keywords: monoclonal B-cell lymphocytosis; B cells; blood donors; chronic lymphocytic leukaemia; flow cytometry. Abstract: Summary Monoclonal B-cell populations have been detected in the peripheral blood of apparently healthy individuals by flow cytometry. In 2005, the term monoclonal B-cell lymphocytosis (MBL) was proposed to describe these findings. MBL may be immunophenotypically similar to chronic lymphocytic leukaemia (CLL) and, like CLL, the prevalence is higher in males and older individuals. We studied the prevalence of MBL in blood donors from the Midwestern United States. Samples from 5141 donors were examined and seven (0*14%) were found to have immunophenotypic characteristics of MBL or CLL. Immunoglobulin heavy chain analysis yielded monoclonality or oligoclonality. Prior and subsequent to the study, an additional undetermined number of blood donors were screened and seven of these expressed immunophenotypic characteristics of MBL or CLL. We thus found a total of 14 healthy blood donors with monoclonal expansions of B-lymphocyte populations. Of these, 12 were presumptively classified as MBL and two as CLL. All but two of the donors were male; the mean age was 59 years. The clinical importance of these findings with regard to transfusion medicine has not been established. Author Affiliation: (1)Saint Luke's Hospital, Kansas City, MO (2)Community Blood Center, Kansas City, MO (3)Flow and Image Cytometry Laboratory, Cellular Therapy and Tissues Branch, Division of Gene and Cell Therapy, US Food and Drug Administration/Center for Biologics Evaluation and Research, NIH, Bethesda, MD, USA Article History: Received 12 August 2007; accepted for publication 20 August 2007 Article note: Jane M. Rachel, Department of Pathology, Saint Luke's Hospital, 4401 Wornall Road, Kansas City, MO 64111, USA., E-mail: jrachel@saint-lukes.org