학술논문
An integrated approach to studying regulation of production of the antibiotic methylenomycin by Streptomyces coelicolor A3(2)
Document Type
Academic Journal
Author
Source
Journal of Bacteriology. March 1992, Vol. 174 Issue 5-6, p1487, 8 p. graph
Subject
Language
ISSN
0021-9193
Abstract
Production of the antibiotic methylenomycin by Streptomyces coelicolor was analyzed using control medium and an antibiotic assay to determine the regulatory mechanisms involved in the synthesis of the antibiotic. Biosynthesis of methylenomycin commences during the transition from primary to secondary metabolism. Further, carbon, nitrogen and an elevated level of phosphates are required for optimum production. Synthesis patterns show that a gene coding for the production of the antibiotic is activated before the gene for resistance, indicating that methylenomycin may induce the activation of the resistance gene.