부산대학교 도서관

Rhodiola rosea L. is one of the most popular adaptogen and anti-stress plants in European and Asiatic traditional medicine. Its pharmacological properties appear to depend on its ability to modulate the activation of several components of the complex stress-response system. Exposure to both physical and psychological stress reduces feeding in rodents. The aim of this work was thus to determine whether in rats an hydroalcoholic R. rosea extract standardized in 3% rosavin and 1% salidroside (RHO) reverses hypophagia induced by (1) physical stress due to 60min immobilization; (2) intracerebroventricular injection of corticotrophinreleasing factor (CRF, 0.2µg/rat), the major mediator of stress responses in mammals; (3) intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS, 100µg/kg); (4) intraperitoneal administration of fluoxetine (FLU, 8 mg/kg). The effect of the same doses of the plant extract was also tested in freely-feeding and in 20 h food-deprived rats. RHO was administered acutely by gavage to male Wistar rats 1h before the experiments. The results show that at 15 and 20 mg/kg, RHO reversed the anorectic effects induced both by immobilization and by intracerebroventricular CRF injection. Moreover, at the same doses, RHO failed to reduce the anorectic effect induced both by LPS and FLU, and did not modify food intake in both freely-feeding and food-deprived rats. These findings strongly demonstrated that RHO is able selectively to attenuate stress-induced anorexia, providing functional evidence of claimed adaptogen and anti-stress properties of Rhodiola rosea L. Keywords Rhodiola rosea, adaptogens, restraint, CRF, anorexia, stress-induced anorexia, CRF-induced anorexia, LPS-induced anorexia, fluoxetineinduced anorexia
Introduction It is well known that stress conditions caused by physiological and environmental factors can induce marked behavioural alterations due to a release of glucocorticoids and activation of a brain [...]