학술논문
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old
Document Type
Report
Author
Source
International Archives of Allergy and Immunology. January 1, 2021, Vol. 182 Issue 2, p146, 7 p.
Subject
Language
English
ISSN
1018-2438
Abstract
Introduction: Allergy to Hymenoptera venom (HV) may lead to life-threatening anaphylaxis. Some of the factors influencing the symptom's severity are still undetermined. The aim of this study was to identify the clinical aspects associated with the most severe reactions in a population with HV allergy, by comparing clinical and immunochemical biomarkers between patients with previous local large reactions (LLRs) and systemic reactions (SRs). Methods: We selected adult patients with a history of HV allergy, with positive diagnostic tests and a correlation with one single Hymenoptera species. Age, gender, atopy, serum basal tryptase (sBT) value, total IgE, venom-specific IgE, history of hypertension, cardiovascular diseases, and hypercholesterolemia were compared between patients with previous LLRs and SRs. Results: 460 adult patients (381 SRs, 79 LLRs) were included. Age (p = 0.0097), male gender (p < 0.0001), arterial hypertension (p = 0.046), hypercholesterolemia (p = 0.009), and higher sBT levels (p = 0.0004) were significantly associated with severe reactions as independent variables. Moreover, considering the previous variables as risk factors, there was a significant and progressive increase in the odds of being Mueller III + IV as the number of positive variables increased. Patients with sBT [GreaterEqual]6.4 ng/mL adjusted for any of the positive variables had increased the risk of Mueller grade IV reaction (p < 0.0001). Conclusion: According to our results, older age, male gender, arterial hypertension, hypercholesterolemia, and increased levels of sBT [GreaterEqual]6.4 ng/mL are risk factors for severe anaphylaxis to HV in adults. Atopy and allergic asthma do not increase the risk of HV-induced SRs. Keywords: Hymenoptera venom, Tryptase, Age, Arterial hypertension, Hypercholesterolemia
Author(s): Elide Anna Pastorello (corresponding author) [a]; Linda Borgonovo [a]; Donatella Preziosi [a]; Jan Walter Schroeder [a]; Valerio Pravettoni [b]; Maria Gloria Aversano [c]; Stefano Pastori [d]; Maria Beatrice Bilò [...]
Author(s): Elide Anna Pastorello (corresponding author) [a]; Linda Borgonovo [a]; Donatella Preziosi [a]; Jan Walter Schroeder [a]; Valerio Pravettoni [b]; Maria Gloria Aversano [c]; Stefano Pastori [d]; Maria Beatrice Bilò [...]