부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1471-0528.2006.00851.x Byline: BA Houtzager (a), SM Hogendoorn (a), DNM Papatsonis (b), JF Samsom (c), HP van Geijn (b), OP Bleker (d), AG van Wassenaer (e) Keywords: Follow up; nifedipine; preterm labour; psychosocial outcome; ritodrine Abstract: Objective To compare the long-term psychosocial and motor effects on children exposed in utero to nifedipine or ritodrine for the management of preterm labour. Design Randomised controlled trial. Setting Multicentre study in two university and one primary hospital in the Netherlands. Population In the original trial, 185 women were randomised to either nifedipine (n= 95) or ritodrine (n= 90). Of the 185 liveborn children, 171 survived (92%), and of these 102 (61%) were followed up at age 9-12 years. Methods Age-specific questionnaires were administered to the parent and teacher. Additional data were obtained from medical records. Main outcome measures Questionnaires were used to assess the child's behavioural-emotional problems, quality of life (QoL), motor functioning, parenting distress and the child's education. Results Of the 171 eligible families, 102 (61%) agreed to participate and completed the questionnaires. Response was equal in the ritodrine group (n= 54 of 83 surviving children, 65%) compared with the nifedipine group (n= 48 of 88 surviving children, 55%). After controlling for differing perinatal characteristics at birth, no significant differences between the groups were detected with respect to long-term behaviour-emotional outcome, QoL, education, motor functioning or parenting distress. Psychosocial outcome was slightly better in the nifedipine group. Conclusions The results do not support any differential postnatal effect of the tocolytic agents ritodrine or nifedipine on the child's long-term psychosocial and motor functioning. The slightly better outcome of children randomised in the nifedipine group is most likely due to more favourable perinatal outcomes in this group. These results merit further investigation in a larger group of survivors. Author Affiliation: (a )Pediatric Psychosocial Department, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (b )Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (c )Department of Pediatrics, Division of Neonatology, VU University Medical Center, Amsterdam, The Netherlands (d )Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (e )Department of Pediatrics, Division of Neonatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Article History: Accepted 7 December 2005. Article note: Correspondence: Dr DNM Papatsonis, Department of Obstetrics and Gynecology, Amphia Hospital Breda, Langendijk 75, 4819 EV Breda, The Netherlands. Email hoog.pap@wxs.nl