부산대학교 도서관

We analyzed the associations of the mechanical strength of dilated ascending aorta wall (intraoperative samples from 30 patients with non-syndromic aneurysms) with tissue MMPs and the cytokine system. Some samples were stretched to break on an Instron 3343 testing machine and the tensile strength was calculated; others were homogenized and the concentrations of MMP-1, MMP-2, MMP-7, their inhibitors (TIMP-1 and TIMP-2), and pro- and anti-inflammatory cytokines were determined by ELISA. Direct correlations between aortic tensile strength and concentrations of IL-10 (r=0.46), TNF[alpha] (r=0.60), and vessel diameter (r=0.67) and an inverse correlation with patient's age (r=-0.59) were revealed. Compensatory mechanisms supporting the strength of the ascending aortic aneurysm are possible. No associations of mMp-1, MMP-7, TIMP-1, and TIMP-2 with tensile strength and aortic diameter were found. Key Words: ascending aortic aneurysm; mechanical strength; metalloproteinases; interleukins; cytokines
Ascending aortic aneurysm (AAA) is a potentially life-threatening disease, which ranks ninth among all causes of death [1]. Surgical repair aimed at preventing of aortal complications, such as aortic dissection [...]