학술논문
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
Document Type
Author abstract
Author
Source
Proceedings of the National Academy of Sciences of the United States. Sept 5, 2006, Vol. 103 Issue 36, p13457, 6 p.
Subject
Language
English
ISSN
0027-8424
Abstract
Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (ll2r[[gamma].sup.-/-]Rag[2.sup.-/-]). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, ll2r[[gamma].sup.-/-]Rag[2.sup.-/-] LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7[r.sup.+] TC[R.sup.+] T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role. imaging | lymphoid organogenesis | transgenic mice