학술논문
Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
Document Type
Report
Author
Source
ejHaem. May 2023, Vol. 4 Issue 2, p483, 5 p.
Subject
Language
English
Abstract
INTRODUCTION Osteosclerosis is a rare disease of skeletal abnormalities with diffuse radiographic appearance of high bone density due to increased bone formation and/or suppressed bone resorption, and is caused by [...]
: Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.
: Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.