학술논문
The Impact of the Implementation of Culture-based Antibiotic Policy on the Incidence of Nosocomial Infections in Neonates Hospitalized in Neonatal Intensive Care Unit in a General Egyptian Hospital in Upper Egypt, 2016-2018
RESEARCH ARTICLE
RESEARCH ARTICLE
Document Type
Academic Journal
Author
Source
Journal of Pure and Applied Microbiology. September 2020, Vol. 14 Issue 3, p1879, 14 p.
Subject
Language
English
ISSN
0973-7510
Abstract
INTRODUCTION Nosocomial infection is one of the common complications in hospitalized patients and is considered as an important cause of morbidity and mortality among different cases in the intensive care [...]
Nosocomial infections mainly are due to inefficient cleaning in association with the uncontrollable prescription of antimicrobials resulting in the emergence of multi-drug resistant pathogens in the hospital environment. Objectives:The study aims to evaluate the impact of the implementation of culture-guided antibiotic policy with strict infection control strategies on the occurrence of nosocomial infections and the resistance pattern of the isolated clinical and environmental pathogens. The study was done in 2 periods. Firstly, (August 2016-April 2017), routine disinfection procedures and the applied antibiotic policy were evaluated. Secondly, according to the results a new antibiotic policy depending on the culture sensitivity results were implemented starting from June 2017 to February 2018 in association with strict infection control practices. As a result of this intervention, A change in the type of the isolated microorganisms was observed. Antibiotic resistance was decreased. Mortality rate was reduced from 14.1% to 9.5% of neonates with nosocomial infections, the number of the prescribed antibiotics didn't exceed 4 antibiotics decreasing the overall cost for neonates' therapy during their hospital stay. Each hospital should have its own antibiotic policy with the application of strict infection control strategies for the control of nosocomial infection. Keywords: NICU, antibiotic policy, culture-based, environmental samples, infection control
Nosocomial infections mainly are due to inefficient cleaning in association with the uncontrollable prescription of antimicrobials resulting in the emergence of multi-drug resistant pathogens in the hospital environment. Objectives:The study aims to evaluate the impact of the implementation of culture-guided antibiotic policy with strict infection control strategies on the occurrence of nosocomial infections and the resistance pattern of the isolated clinical and environmental pathogens. The study was done in 2 periods. Firstly, (August 2016-April 2017), routine disinfection procedures and the applied antibiotic policy were evaluated. Secondly, according to the results a new antibiotic policy depending on the culture sensitivity results were implemented starting from June 2017 to February 2018 in association with strict infection control practices. As a result of this intervention, A change in the type of the isolated microorganisms was observed. Antibiotic resistance was decreased. Mortality rate was reduced from 14.1% to 9.5% of neonates with nosocomial infections, the number of the prescribed antibiotics didn't exceed 4 antibiotics decreasing the overall cost for neonates' therapy during their hospital stay. Each hospital should have its own antibiotic policy with the application of strict infection control strategies for the control of nosocomial infection. Keywords: NICU, antibiotic policy, culture-based, environmental samples, infection control