학술논문
Effects of exogenous crosslinking on in vitro tensile and compressive moduli of lumbar intervertebral discs
Document Type
Author abstract
Source
Clinical Biomechanics. Jan, 2007, Vol. 22 Issue 1, p14, 7 p.
Subject
Language
English
ISSN
0268-0033
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.clinbiomech.2006.08.001 Byline: Shih-Youeng Chuang (a), Russell M. Odono (b), Thomas P. Hedman (c) Keywords: Intervertebral disc; Degeneration; Annulus fibrosus; Collagen crosslinks; Modulus Abstract: Collagen crosslinks may play a vital role in preventing ongoing disc degeneration. Age-accumulating crosslinks have been thought to increase brittleness and reduce fatigue resistance. However recent studies have demonstrated increases in fatigue resistance, joint stability and nutritional flow properties resulting from crosslink augmentation. In this study, multi-directional moduli of bovine lumbar intervertebral discs were measured in vitro, including circumferential tension, radial compression, axial tension, and axial compression in control and crosslinked specimens. Author Affiliation: (a) Department of Orthopaedic Surgery, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Road, Neihu District, Taipei City, Taipei 114, Taiwan (b) University of California Los Angeles, Department of Organismic Biology, Ecology, & Evolution, 621 Charles E. Young Dr. South, Los Angeles, CA 90095-1606, USA (c) Institute for Spinal Disorders, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Davis Research Building, 6th Floor, Room D-6068, Los Angeles, CA 90048, USA Article History: Received 19 April 2005; Accepted 9 August 2006