학술논문

RNA: a double-edged sword in genome maintenance
Document Type
Report
Source
Nature Reviews Genetics. November, 2020, Vol. 21 Issue 11, p651, 20 p.
Subject
United States
Language
English
ISSN
1471-0056
Abstract
All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such as autoimmune disorders, neurodegenerative diseases and cancer. Traditionally, genome maintenance has been viewed largely in terms of DNA-protein interactions. However, emerging evidence points to RNA as a key modulator of genome stability, with seemingly opposing roles in promoting chromosomal instability and protecting genome integrity. Unravelling the mechanistic and contextual basis of this duality will not only improve our understanding of the interfaces between RNA and the genome but will also provide important insights into how disrupted RNA metabolism contributes to disease origin, laying the foundation for targeted intervention. Genome instability can lead to a number of human diseases, including neurodegeneration and cancer. In this Review, Zong et al. discuss the various ways in which RNA can both promote genome instability and contribute to genome maintenance.
Author(s): Dali Zong [sup.1] , Philipp Oberdoerffer [sup.2] , Pedro J. Batista [sup.3] , André Nussenzweig [sup.1] Author Affiliations: (1) Laboratory of Genome Integrity, National Cancer Institute, National Institutes of [...]