학술논문
Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. May 24, 1994, Vol. 91 Issue 11, p5002, 5 p. photograph
Subject
Language
ISSN
0027-8424
Abstract
Phosphorylation of protein-tyrosine-phosphatase 2C (PTP2C) by 44-kDa mitogen-activated protein kinase (MAP kinase) serine residues of untreated PC12 rat cells inhibits the PTP2C enzyme activity. The epidermal growth factor (EGF) receptor functions as substrates. The inhibitory effect indicates negative regulatory activity of MAP kinase on PTP2C.