부산대학교 도서관

We studied the effect of the [H.sub.2]S donor (NaHS, 1-500 [micro]M) on the contractile responses of isolated aortic smooth muscle segments from rats with metabolic syndrome induced by high-fat, high-carbohydrate diet. It was found that the vasorelaxing effect of NaHS (5-100 [micro]M) decreased in under conditions of MS. The endothelial NO synthase inhibitor L-NAME (100 [micro]M) suppressed the effect of NaHS, while cystathionine-gamma-lyase inhibitor PAG (100 [micro]M) decreased the vasodilating effects of acetylcholine (0.1-100 [micro]M). Application of endogenous NO precursor L-arginine (1 mM) potentiated in the effects of [H.sub.2]S donor NaHS. Thus, the contractile activity of vascular smooth muscles in metabolic syndrome is determined by not only the effect of [H.sub.2]S, but also the influence of NO. Key Words: hydrogen sulfide; nitric oxide; vascular smooth muscles; metabolic syndrome
Hydrogen sulfide ([H.sub.2]S), along with nitric oxide (NO) and carbon monoxide (CO) are members of the gasotransmitter family [10]. [H.sub.2]S is produced through various endogenous enzymatic and non-enzymatic pathways and [...]