학술논문

Dynamic Changes of Post-Ischemic Hepatic Microcirculation Improved by a Pre-Treatment of Phosphodiesterase-3 Inhibitor, Milrinone
Document Type
Report
Source
Journal of Surgical Research. Dec, 2006, Vol. 136 Issue 2, p209, 10 p.
Subject
Esterases
Surgical clinics
Cyclic adenylic acid
Universities and colleges
Milrinone
Language
English
ISSN
0022-4804
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jss.2006.05.038 Byline: Makoto Kume ([cor]), Ramin Banafsche ([cor]), Yuzo Yamamoto, Yoshio Yamaoka, Rainer Nobiling, Martha-Maria Gebhard, Ernst Klar ([cor])(A[paragraph]) Keywords: cyclic AMP; phosphodiesterase inhibitor; ischemia-reperfusion injury; ischemic pre-conditioning; microcirculation Abstract: Phosphodiesterase-3 inhibition has been shown to attenuate hepatic warm ischemia-reperfusion injury. The aim of this study was to investigate the effect of milrinone, phosphodiesterase-3 inhibitor, on post-ischemic microcirculation of rat livers by intravital microscopy. Author Affiliation: ([cor]) Department of General Surgery, Surgical Clinic, University of Heidelberg, Heidelberg, Germany (a ) Department of Experimental Surgery, Surgical Clinic, University of Heidelberg, Heidelberg, Germany (a ) Department of Gastroenterological Surgery, Akita University School of Medicine, Akita, Japan (As.) Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan (A[paragraph]) Department of Surgery, University of Rostock, Rostock, Germany Article History: Received 14 June 2005 Article Note: (footnote) 1 Makoto Kume and Ramin Banafsche contributed equally to this work. This work was supported by the Deutsche Forschungsgemeinschaft, Germany; the 27th Grant for Scientists studying abroad, Kanae Foundation, Tokyo, Japan; by a Grant-in-Aid for Scientific Research (C); and by a Grant JSPS-RFTF 96I00204 from the Japan Society for the Promotion of Science, Tokyo, Japan.