학술논문
Dynamic Changes of Post-Ischemic Hepatic Microcirculation Improved by a Pre-Treatment of Phosphodiesterase-3 Inhibitor, Milrinone
Document Type
Report
Author
Source
Journal of Surgical Research. Dec, 2006, Vol. 136 Issue 2, p209, 10 p.
Subject
Language
English
ISSN
0022-4804
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jss.2006.05.038 Byline: Makoto Kume ([cor]), Ramin Banafsche ([cor]), Yuzo Yamamoto, Yoshio Yamaoka, Rainer Nobiling, Martha-Maria Gebhard, Ernst Klar ([cor])(A[paragraph]) Keywords: cyclic AMP; phosphodiesterase inhibitor; ischemia-reperfusion injury; ischemic pre-conditioning; microcirculation Abstract: Phosphodiesterase-3 inhibition has been shown to attenuate hepatic warm ischemia-reperfusion injury. The aim of this study was to investigate the effect of milrinone, phosphodiesterase-3 inhibitor, on post-ischemic microcirculation of rat livers by intravital microscopy. Author Affiliation: ([cor]) Department of General Surgery, Surgical Clinic, University of Heidelberg, Heidelberg, Germany (a ) Department of Experimental Surgery, Surgical Clinic, University of Heidelberg, Heidelberg, Germany (a ) Department of Gastroenterological Surgery, Akita University School of Medicine, Akita, Japan (As.) Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan (A[paragraph]) Department of Surgery, University of Rostock, Rostock, Germany Article History: Received 14 June 2005 Article Note: (footnote) 1 Makoto Kume and Ramin Banafsche contributed equally to this work. This work was supported by the Deutsche Forschungsgemeinschaft, Germany; the 27th Grant for Scientists studying abroad, Kanae Foundation, Tokyo, Japan; by a Grant-in-Aid for Scientific Research (C); and by a Grant JSPS-RFTF 96I00204 from the Japan Society for the Promotion of Science, Tokyo, Japan.