학술논문
Nutritional Global Status and Its Impact in Crohn's Disease
Original Article
Original Article
Document Type
Report
Author
Prieto, Juliana Midori Iqueda; Andrade, Adriana Ribas; Magro, Daniela Oliveira; Imbrizi, Marcello; Nishitokukado, Ieda; Ortiz-Agostinho, Carmen Lucia; dos Santos, Fabiana Maria; Luzia, Liania Alves; Rondo, Patricia Helen de Carvalho; Leite, Andre Zonetti de Arruda; Carrilho, Flair Jose; Sipahi, Aytan Miranda
Source
Journal of the Canadian Association of Gastroenterology. December 2021, Vol. 4 Issue 6, p290, 6 p.
Subject
Language
English
ISSN
2515-2084
Abstract
Introduction A number of nutritional disorders can be present in patients with Crohn's disease (CD) such as anorexia, malabsorption, protein-losing enteropathy or increased energy demand due to hypermetabolism which might [...]
Background: Malnutrition among inflammatory bowel disease (IBD) subjects is well documented in literature and may emerge from factors including inadequate dietary intake, malabsorption and disease activity. The aim of this study was to complete a comprehensive nutrition assessment and explore what possibilities may help bring a better quality of life for IBD subjects. Methods: Nutritional status based on biochemical tests, body composition and body mass index (BMI). Food intake was assessed by an alternate 3-day food record and the adequacy of intake was evaluated according to national and international references. Clinical disease activity was evaluated by the Harvey-Bradshaw index and CRP levels. Results: The study included 217 patients and 65 controls, where 54.4% of these patients were classified as normal weight with a mean BMI lower than controls (23.8 [+ or -] 4.9 versus 26.9 [+ or -] 4.8 kg/[m.sup.2], P = 0.02). Patients with disease activity showed more overweight and obesity than patients with controlled disease. Vitamin B12 deficiency was present in 19% of Crohn's disease (CD), mainly in patients with ileal commitment and small bowel resections. Anemia was present in 21.7% of patients, being more common in patients with active disease (25%) and bowel resection (23%). Regarding calorie intake (EI), CD group ingested more than controls (1986.3 [+ or -] 595.9 kcal versus 1701.8 [+ or -] 478.9 kcal; P = 0.003). Conclusions: CD patients presented micronutrient deficiency when compared with controls, explained for other reasons than intake restrictions. Also, fat excess might have contributed to disease burden as continuously reported in the literature. Keywords: Crohn's disease; Diet; Dietary intake; Disease activity; Nutritional status
Background: Malnutrition among inflammatory bowel disease (IBD) subjects is well documented in literature and may emerge from factors including inadequate dietary intake, malabsorption and disease activity. The aim of this study was to complete a comprehensive nutrition assessment and explore what possibilities may help bring a better quality of life for IBD subjects. Methods: Nutritional status based on biochemical tests, body composition and body mass index (BMI). Food intake was assessed by an alternate 3-day food record and the adequacy of intake was evaluated according to national and international references. Clinical disease activity was evaluated by the Harvey-Bradshaw index and CRP levels. Results: The study included 217 patients and 65 controls, where 54.4% of these patients were classified as normal weight with a mean BMI lower than controls (23.8 [+ or -] 4.9 versus 26.9 [+ or -] 4.8 kg/[m.sup.2], P = 0.02). Patients with disease activity showed more overweight and obesity than patients with controlled disease. Vitamin B12 deficiency was present in 19% of Crohn's disease (CD), mainly in patients with ileal commitment and small bowel resections. Anemia was present in 21.7% of patients, being more common in patients with active disease (25%) and bowel resection (23%). Regarding calorie intake (EI), CD group ingested more than controls (1986.3 [+ or -] 595.9 kcal versus 1701.8 [+ or -] 478.9 kcal; P = 0.003). Conclusions: CD patients presented micronutrient deficiency when compared with controls, explained for other reasons than intake restrictions. Also, fat excess might have contributed to disease burden as continuously reported in the literature. Keywords: Crohn's disease; Diet; Dietary intake; Disease activity; Nutritional status