학술논문
The possibility of predicting prolongation of the pharmacological action of biologically active polymeric substances
Document Type
Academic Journal
Author
Source
International Polymer Science and Technology. November 1, 2012, Vol. 39 Issue 11, pT/21, 7 p.
Subject
Language
English
ISSN
0307-174X
Abstract
The physicochemical properties and the formation, stability, and dissociation constants of complexes of poly acids with organic bases possessing physiological activity were determined by methods of potentiometric titration, conductometry, and equilibrium dialysis, and by biological methods. The relationship between the level of physicochemical characteristics of complexes and the possibility of predicting the prolonged pharmacological (antimicrobial, anaesthetising) action of physiologically active substances in complexes with polymers was established.
The suggestion that high-molecular-weight compounds, in particular synthetic water-soluble (co)polymers, could be used to modify low-molecular-weight compounds possessing pharmacological activity--medicines--was first mooted by Sergei Nikolaevich Ushakov [1]. Work on the [...]
The suggestion that high-molecular-weight compounds, in particular synthetic water-soluble (co)polymers, could be used to modify low-molecular-weight compounds possessing pharmacological activity--medicines--was first mooted by Sergei Nikolaevich Ushakov [1]. Work on the [...]