학술논문
Human leukocyte antigen-DR expression in peripheral blood mononuclear cells from healthy donors influenced by the sera of injured patients prone to severe sepsis
Document Type
Author abstract
Author
Source
Intensive Care Medicine. Dec 2003, Vol. 29 Issue 12, p2285, 6 p.
Subject
Language
English
ISSN
0342-4642
Abstract
Objective To study the influence of sera from severely injured patients on the human leukocyte antigen (HLA)-DR expression of normal peripheral blood mononuclear cells (PBMC). Design In vitro study. Setting University hospital. Patients and participants Sera from 34 patients were obtained within 8 h after trauma. Seventeen of these patients developed posttraumatic sepsis (sepsis group) and 17 recovered without infectious complications. Sera from ten healthy individuals served as controls. Phytohemagglutinin (PHA)-activated PBMC from 44 healthy donors were used to study the effects of a patient's serum. Measurements and results Medium containing 5% of serum from the sepsis group significantly (p Conclusions Reduced cellular immunity and, therefore, immunodeficiency after trauma appears to be caused by soluble factors influencing T cell function in particular.