부산대학교 도서관

Type 1 and type 2 diabetes have different causative mechanisms but the same metabolic outcome, i.e. hyperglycemia. Yet there have been no studies on the differential prevalence of complications in these two types of diabetes. In our experiment, we studied cardiovascular, cognitive and hearing functions in two types of mice --Wild type (WT), Akita and db/db mice (n=6 in each group). For all mice, body weight and blood glucose were measured. To assess cardiovascular functions, blood pressure and left ventricular ejection fraction (LVEF) were measured. Novel object recognition test (NORT) was performed to evaluate cognitive function and auditory brainstem response (ABR) was elicited to assess hearing. Body weight was significantly less in Akita and more in db/db as compared to WT mice. Blood glucose and blood pressure were higher in both types of diabetic mice. Left ventricular dysfunction was noticed in both groups of diabetic mice. NORT calculated discrimination index was decreased in both types of diabetic mice indicating significantly compromised cognitive abilities as compared to WT. ABR threshold was elevated in Akita as well as db/db, but more so in the latter. Blood glucose significantly correlated with blood pressure, LVEF, discrimination index, and ABR threshold, but not with body weight. Hence, we concluded that cardiovascular and cognitive functions were similarly affected in both types of diabetics. On the other hand, ABR threshold was significantly raised in the obese db/db mice, more so than in the Akita, probably due to several concurrent mechanisms affecting the cochlea in db/db mice.
S064 Seema Bhargava (1,2), Srikanth Givvimani (2), Ilza Medina (2), Nithya Narayanan (2), Naira Metreveli (2), Suresh C Tyagi (2) (1) Department of Biochemistry, Sir Gangaram Hospital, New Delhi, India, [...]