부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bjps.2005.09.027 Byline: A. Tahir, J.B. Webb, G. Allen, J.D. Nancarrow Abstract: EMLA.sup.[R] cream is used in plastic surgery as a topical anaesthetic to harvest split skin grafts. It has been observed that the skin appears pale and oedematous after the application of EMLA.sup.[R]. The aim our study was to determine the effect of EMLA.sup.[R] with an occlusive dressing on skin thickness using a high frequency ultrasound. Twenty volunteers took part in this study after approval from the ethics committee. An area of skin was marked on both thighs and the skin thickness of each, measured using ultrasound. EMLA.sup.[R] with an occlusive dressing was applied to one thigh. This was removed after at least 2h of application time but at different time points and skin thickness of each thigh measured again. Data was analysed using t-test and Pearson's correlation. Mean age in years[+ or -]SD (range) was 36.1[+ or -]12.1 (23-61). Male:female ratio was 8:12. Mean skin thickness[+ or -]SEM increased from 1.86[+ or -]0.055mm prior to EMLA.sup.[R] application to 1.96[+ or -]0.051mm post-EMLA.sup.[R] application p=0.02. There was a significant correlation between the increase in skin thickness and duration of application of EMLA.sup.[R] cream (p= Author Affiliation: Department of Plastic and Reconstructive Surgery, Selly Oak Hospital, University Hospital Birmingham, Selly Oak, Birmingham B29 6JD, UK Article History: Received 23 February 2005; Accepted 8 September 2005 Article Note: (footnote) [star]This work was presented in the West Midlands Plastic and Burns Surgery National meeting at University Hospital Birmingham, UK on 30th October 2004.