학술논문
Serum zinc concentration in patients with myocardial infarction: a retrospective study
Document Type
Academic Journal
Author
Source
BMC Cardiovascular Disorders. February 14, 2024, Vol. 24 Issue 1
Subject
Language
English
ISSN
1471-2261
Abstract
Author(s): Atsushi Tanita[sup.1], Shigeto Namiuchi[sup.1], Kenta Onodera[sup.1], Shinichiro Sunamura[sup.1], Tsuyoshi Ogata[sup.1], Kazuki Noda[sup.1] and Toru Takii[sup.1] Background Zinc is an essential trace element and a component of several metalloenzymes with [...]
Background Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction. Methods Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 [micro]g/dL at admission, n = 111) and high zinc group ([greater than or equal to] 66 [micro]g/dL at admission, n = 132). During follow-up (mean [+ or -] SD: 734 [+ or -] 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively. Results The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11-221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048). Conclusion Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction. Keywords: Zinc, Heart failure, Myocardial infarction, Oxidative stress
Background Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction. Methods Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 [micro]g/dL at admission, n = 111) and high zinc group ([greater than or equal to] 66 [micro]g/dL at admission, n = 132). During follow-up (mean [+ or -] SD: 734 [+ or -] 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively. Results The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11-221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048). Conclusion Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction. Keywords: Zinc, Heart failure, Myocardial infarction, Oxidative stress