학술논문

Age-related changes in the neuromuscular development of the internal anal sphincter
Document Type
Report
Source
Journal of Pediatric Surgery. June, 2008, Vol. 43 Issue 6, p1106, 5 p.
Subject
Language
English
ISSN
0022-3468
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jpedsurg.2008.02.040 Byline: Reiji Nakano (a), Thambipillai Sri Paran (a), Udo Rolle (b), Prem Puri (a) Keywords: Internal anal sphincter; Rectoanal inhibitory reflex; Enteric nervous system; Smooth muscle; Developmental changes Abstract: The internal anal sphincter (IAS) plays an important role in the pathophysiology of constipation and incontinence. We hypothesized that functional bowel obstruction in premature infants is because of a poorly developed IAS. We investigated the neuromuscular development of IAS in fetal, newborn, and adolescent pigs. Author Affiliation: (a) The Children's Research Center, Our Lady's Children's Hospital, Dublin 12, Ireland (b) Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany Article History: Received 4 February 2008; Accepted 9 February 2008 Article Note: (footnote) Presented at the 59th Annual Meeting of the Section on Surgery, American Academy of Pediatrics, San Francisco, CA, October 25-27, 2007.