학술논문
How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort
Document Type
Report
Author
Suarez-García, Ines; Alejos, Belén; Pérez-Elías, Maria-Jesús; Iribarren, Jose-Antonio; Hernando, Asunción; Ramírez, Margarita; Tasias, María; Pascual, Mario; Jarrin, Inma; Hernando, Victoria; Moreno, Santiago; Jarrín, Inma; Dalmau, David; Navarro, Maria Luisa; González, Maria Isabel; Garcia, Federico; Poveda, Eva; Iribarren, Jose Antonio; Gutiérrez, Félix; Rubio, Rafael; Vidal, Francesc; Berenguer, Juan; González, Juan; Muéoz-Fernández, M.Ãngeles; Jarrin, Inmaculada; Moreno, Cristina; Iniesta, Carlos; Sousa, Luis Miguel Garcia; Perez, Nieves Sanz; Rava, Marta; Fernández, Irene Consuegra; Merino, Esperanza; García, Gema; Portilla, Irene; Agea, Iván; Portilla, Joaquín; Sánchez-Payá, José; Rodríguez, Juan Carlos; Gimeno, Lina; Giner, Livia; Díez, Marcos; Carreres, Melissa; Reus, Sergio; Boix, Vicente; Torrús, Diego; Lirola, Ana López; García, Dácil; Díaz-Flores, Felicitas; Gómez, Juan Luis; del Mar Alonso, María; Pelazas, Ricardo; Hernández, Jehovana; Alemán, María Remedios; Hernández, María Inmaculada; Asensi, Víctor; Valle, Eulalia; Carmenado, María Eugenia Rivas; Secades, Tomás Suárez-Zarracina; Is, Laura Pérez; Pulido, Federico; Bisbal, Otilia; Domínguez, Lourdes; Crestelo, David Rial; Bermejo, Laura; Santacreu, Mireia; Iribarren, José Antonio; Arrizabalaga, Julio; Aramburu, María José; Camino, Xabier; Rodríguez-Arrondo, Francisco; von Wichmann, Miguel Ãngel; Tomé, Lidia Pascual; Goenaga, Miguel Ãngel; Bustinduy, Mª Jesús; Azkune, Harkaitz; Ibarguren, Maialen; Lizardi, Aitziber; Kortajarena, Xabier; Oyaga, Mª Pilar Carmona; Igartua, Maitane Umerez; Masiá, Mar; Padilla, Sergio; Robledano, Catalina; Colomé, Joan Gregori; Adsuar, Araceli; Pascual, Rafael; Fernández, Marta; García, José Alberto; Barber, Xavier; Re, Vanessa Agullo; Abellán, Javier Garcia; Pérez, Reyes+ Pascual; Roca, María; Muga, Roberto; Sanvisens, Arantza; Fuster, Daniel; de Quirós, Juan Carlos López Bernaldo; Gutiérrez, Isabel; Padilla, Belén; Gijón, Paloma; Aldamiz-Echevarría, Teresa; Tejerina, Francisco; Parras, Francisco José; Balsalobre, Pascual; Diez, Cristina; Latorre, Leire Pérez; Fanciulli, Chiara; Peraire, Joaquín; Viladés, Consuelo; Veloso, Sergio; Vargas, Montserrat; Olona, Montserrat; Rull, Anna; Rodríguez-Gallego, Esther; Alba, Verónica; Castellanos, Alfonso Javier; López-Dupla, Miguel; Alonso, Marta Montero; Aldeguer, José López; Juliá, Marino Blanes; Pitarch, María Tasias; Hernández, Iván Castro; Muéoz, Eva Calabuig; Tovar, Sandra Cuéllar; Lletí, Miguel Salavert; Navarro, Juan Fernández; González-Garcia, Juan; Arnalich, Francisco; Arribas, José Ramón; de la Serna, Jose Ignacio Bernardino; Busca, Carmen; Cano, Joanna; Cardiéanos, Julen; Castro, Juan Miguel; Hierro, Ana Delgado; Escosa, Luis; Herranz, Pedro; Hontaéón, Víctor; García-Bujalance, Silvia; López-Hortelano, Milagros García; González-Baeza, Alicia; de Miguel, Rosa; Martín-Carbonero, Maria Luz; Mayoral, Mario; Mellado, Maria Jose; Micán, Rafael Esteban; Montejano, Rocio; Montes, María Luisa; Moreno, Victoria; Pérez-Valero, Ignacio; Cebrián, Guadalupe Rúa; Rodés, Berta; Sainz, Talia; Sendagorta, Elena; Valencia, Eulalia; Blanco, José Ramón; Oteo, José Antonio; Ibarra, Valvanera; Metola, Luis; Sanz, Mercedes; Pérez-Martínez, Laura; Arazo, Piedad; Sampériz, Gloria; Jaén, Angels; Sanmartí, Montse; Cairó, Mireia; Martinez-Lacasa, Javier; Velli, Pablo; Font, Roser; Martinez, Marina; Aiello, Francesco; Marcotegui, Maria Rivero; Repáraz, Jesús; de Alda, María Gracia Ruiz; de León Cano, María Teresa; de Galarreta, Beatriz Pierola Ruiz; Amengual, María José; Navarro, Gemma; Garcia, Manel Cervantes; Isbert, Sonia Calzado; Vilasaro, Marta Navarro; de los Santos, Ignacio; Sanz, Jesús Sanz; Aparicio, Ana Salas; Cepeda, Cristina Sarria; Fraile, Lucio Garcia-Fraile; Gayo, Enrique Martín; Osorio, José Luis Casado; Nuéez, Fernando Dronda; Zamora, Ana Moreno; Elías, Maria Jesús Pérez; Gutiérrez, Carolina; Madrid, Nadia; del Campo Terrón, Santos; Villar, Sergio Serrano; Gallego, Maria Jesús Vivancos; Sanz, Javier Martínez; Urroz, Usua Anxa; Velasco, Tamara; Bernal, Enrique; Sanchez, Alfredo Cano; García, Antonia Alcaraz; Urbieta, Joaquín Bravo; Perez, Ãngeles Muéoz; Alcaraz, Maria Jose; del Carmen Villalba, Maria; García, Federico; Quero, José Hernández; Medina, Leopoldo Muéoz; Alvarez, Marta; Chueca, Natalia; García, David Vinuesa; Martinez-Montes, Clara; Beltrán, Carlos Guerrero; de Salazar Gonzalez, Adolfo; Lopez, Ana Fuentes; Del Romero, Jorge; Utrilla, Montserrat Raposo; Rodríguez, Carmen; Puerta, Teresa; Carrió, Juan Carlos; Vera, Mar; Ballesteros, Juan; Ayerdi, Oskar; Antela, Antonio; Losada, Elena; Riera, Melchor; Peéaranda, María; Ribas, Mª Angels; Campins, Antoni A.; Vidal, Carmen; Fanjul, Francisco; Murillas, Javier; Homar, Francisco; Vilchez, Helem H.; Martin, Maria Luisa; Payeras, Antoni; Santos, Jesús; Ayerbe, Cristina Gómez; Viciana, Isabel; Palacios, Rosario; López, Carmen Pérez; Gonzalez-Domenec, Carmen Maria; Viciana, Pompeyo; Espinosa, Nuria; López-Cortés, Luis Fernando; Podzamczer, Daniel; Imaz, Arkaitz; Tiraboschi, Juan; Silva, Ana; Saumoy, María; Prieto, Paula; Ribera, Esteban; Curran, Adrian; Sierra, Julián Olalla; Stachowski, Javier Pérez; del Arco, Alfonso; de la torre, Javier; Prada, José Luis; de Lomas Guerrero, José María García; Martínez, Onofre Juan; Vera, Francisco Jesús; Martínez, Lorena; García, Josefina; Alcaraz, Begoéa; Jimeno, Amaya; Iglesias, Ãngeles Castro; Souto, Berta Pernas; de Cea, Ãlvaro Mena; Muéoz, Josefa; Zubero, Miren Zuriée; Baraia-Etxaburu, Josu Mirena; Ugarte, Sofía Ibarra; Beneitez, Oscar Luis Ferrero; de Munain, Josefina López; López, Mª Mar Cámara; de la Peéa, Mireia; Lopez, Miriam; Azkarreta, Iéigo Lopez; Galera, Carlos; Albendin, Helena; Pérez, Aurora; Iborra, Asunción; Moreno, Antonio; Merlos, Maria Angustias; Vidal, Asunción; Meca, Marisa; Amador, Concha; Pasquau, Francisco; Ena, Javier; Benito, Concha; Fenoll, Vicenta; Anguita, Concepción Gil; Rabasa, José Tomás Algado; Suárez-García, Inés; Malmierca, Eduardo; González-Ruano, Patricia; Rodrigo, Dolores Martín; Seco, Mª Pilar Ruiz; Mohamed-Balghata, Mohamed Omar; Vidal, María Amparo Gómez; de Zarraga, Miguel Alberto; Pérez, Vicente Estrada; Molina, Maria Jesús Téllez; García, Jorge Vergas; Moreno, Juncal Pérez-Somarriba; Górgolas, Miguel; Cabello, Alfonso; Ãlvarez, Beatriz; Prieto, Laura; Moreno, José Sanz; Caso, Alberto Arranz; Gutiérrez, Cristina Hernández; Mena, María Novella; Puerto, María José Galindo; Vilalta, Ramón Fernando; Ribera, Ana Ferrer; Román, Antonio Rivero; Juárez, Antonio Rivero; López, Pedro López; Sánchez, Isabel Machuca; Casas, Mario Frias; Espejo, Angela Camacho; Jiménez, Miguel Cervero; Perea, Rafael Torres; Pineda, Juan A.; Mayo, Pilar Rincón; Sanchez, Juan Macías; Gutierrez, Nicolás Merchante; Real, Luis Miguel; Gomez, Anais Corma; Fuertes, Marta Fernández; Gonzalez-Serna, Alejandro; Pérez, Alexandre; Crespo, Manuel; Morano, Luis; Miralles, Celia; Ocampo, Antonio; Pousada, Guillermo
Source
BMC Women's Health. May 28, 2021, Vol. 21 Issue 1
Subject
Language
English
ISSN
1472-6874
Abstract
Author(s): Ines Suarez-García[sup.1,2] , Belén Alejos[sup.3] , Maria-Jesús Pérez-Elías[sup.4] , Jose-Antonio Iribarren[sup.5] , Asunción Hernando[sup.2,6] , Margarita Ramírez[sup.7] , María Tasias[sup.8] , Mario Pascual[sup.9] , Inma Jarrin[sup.3] , Victoria Hernando[sup.3] [...]
Background To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women. Keywords: Menopause, HIV infection, Symptoms, Anxiety, Depression
Background To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women. Keywords: Menopause, HIV infection, Symptoms, Anxiety, Depression